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Practical Radiation Oncology associate section editor Ashley Weiner, MD, PhD, of University of North Carolina - Chapel Hill hosts a conversation on the ASTRO Radiation Therapy Summary of the ASCO Guideline on Management of Stage III Non-Small Cell Lung Cancer. Two of the authors, Charles Simone MD, of the New York Proton Center and Memorial Sloan Kettering Cancer Center and George Rodrigues, MD, PhD of the London Health Sciences Center and University of Western Ontario discuss the updated guidelines and review specific questions related to the management of patients with Stage III NSCLC. They focus on the key clinical questions around neoadjuvant therapy, adjuvant therapy, and definitive chemoradiotherapy for Stage III lung cancer with a thorough review of the guidelines and insights into their own clinical expertise in the multidisciplinary management of NSCLC.