The first crew arrived at the International Space Station (ISS) 25 years ago. Since then, almost 300 people from some 20 nations have visited the orbiting laboratory. If you were born after November 2000, for your entire life, there has always been someone living in space. Astronauts Tim Peake and Nicole Stott share their experiences of living on the ISS. Nasa’s latest venture, Artemis II, is due for launch in the next few months. The ten-day mission will carry four astronauts further than any human has gone before, in a loop far beyond the Moon. It’s the latest stage of the US-led plan to eventually land humans on the lunar surface for the first time since 1972. We bring together astronaut Mike Massimino, who has flown to space twice and starred (as an astronaut) in The Big Bang Theory. We also hear from former Nasa researcher and AI expert, Kiri Wagstaff, and Les Johnson, former senior engineer at Nasa and now the CEO of Infinite Frontiers Consulting.