Best Science Medicine Podcast - BS without the BS

In episode 630, Jamie and James invite Karenn Chan back to the podcast and we go over all the evidence to answer the question, is giving oral vitamin B12 as effective as intramuscular vitamin B12? Lots of people still get these intramuscular shots, but have a listen to the podcast to see if this really still makes sense.

Show Notes

In episode 629, Jamie and James invite Karenn Chan to the podcast for the first time. We go over the evidence for the very important topic of if and when to stop medications for dementia. We’ll give you all the numbers you need to have informed conversations with patients and caregivers of people with dementia. Have a listen and hopefully you will find the discussion useful.

Show Notes

In episode 628, Jamie and James invite Jennifer Young back to the podcast to talk about the very important topic of sleep and what to use instead of medications. We go over all the evidence for cognitive behavioural therapy for insomnia and the numbers look pretty impressive. Have a listen and hopefully you will be impressed by the benefit.

Show Notes

In episode 627, Tina and James again invite Danielle Perry and Caitlin Finley back to the podcast to answer the question, in children with peanut allergy, does oral immunotherapy increase peanut tolerance, and what are the adverse effects? It does work, but it is not a cure, so you need to know the numbers and the important context – you’ll get this from this podcast.

Show Notes

In episode 626, Tina and James invite Caitlin Finley and Danielle Perry to the podcast to discuss the evidence for using hydrocortisone or pimecrolimus for atopic dermatitis in patients under the age of 2. They do work, so check out the podcast for all the numbers and the important context.

Show Notes

In episode 625, Mike K and James invite Danielle Perry and Tony Nickonchuk to the podcast to talk about the evidence around blood pressure measurement techniques. You might be surprised by what does and does not influence blood pressure measurements. Check out the podcast.

Show Notes

In episode 624, James and Mike K invite Tony Nickonchuk to go over all the new evidence we have for the PCSK9 inhibitors. First, we discuss whether or not the evidence addresses the issue of primary versus secondary prevention. We then give you all the numbers and the context you need to allow you to discuss these with your patients.

Show Notes

PEIP Conference Oct 16-17, 2026

In episode 623, Jamie and James invite Samantha Moe back again to talk about the never-ending debate as to what is the target for systolic blood pressure. We look at the evidence and then try to put it into a reasonable context because at best the evidence is always nuanced. But at least you will now know the numbers.

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In episode 622, Jamie and James invite Émélie Braschi back again to talk about if we should be using inhalers that combine corticosteroids and beta-agonists as rescue inhalers. We go over the best available evidence and then try to put the findings into context.

Show Notes

In episode 621, Tina, James and Mike K talk about the evidence around whole-body MRIs. We discuss how many abnormalities are found, how many cancers are actually found, and finally the lost opportunity costs. You need to know these numbers to talk to your patients about the value or lack thereof of doing this test.

Show Notes

MEME conference May8/9 2026 in Vancouver