In the series finale, we explore a different type of uncertainty—the uncertainty that arises around the healthcare system itself. This episode follows Ed Stratton, a stage IV cancer patient who beat his cancer, only to be denied a life-saving liver transplant by his insurance provider. His daughter Erin, armed with industry knowledge and unshakable determination, teams up with a healthcare whistleblower and an AI-powered startup to wage an extraordinary battle for his life. We end with a quiet reflection on uncertainty, and what it means to keep going. 

Find show notes, transcripts, and more at thenocturnists.org, and subscribe to our substack.

The "Uncertainty in Medicine" series is generously funded by the ABIM Foundation, by the Josiah Macy Jr. Foundation, and the Gordon & Betty Moore Foundation.

The Nocturnists is supported by The California Medical Association and donations from listeners like you.

Host: Emily Silverman, MD

Uncertainty Correspondent: Alexa Miller

Series Illustrations by Eleni Debo

What does it mean to live well in a world where nothing is certain — not in medicine, not in life? In this episode, we follow a high school teacher who asks his students to examine “the good life” through philosophy, Buddhism, and existential inquiry. We meet two women — a Buddhist monk and a disability rights advocate — who bring spiritual wisdom to the messy realities of illness, caregiving, and embodiment. Their stories, woven with reflections on impermanence, suffering, and compassion, offer a new way of thinking about uncertainty: not as something to fix, but as something to live with.

Find show notes, transcripts, and more at thenocturnists.org, and subscribe to our substack.

The "Uncertainty in Medicine" series is generously funded by the ABIM Foundation, by the Josiah Macy Jr. Foundation, and the Gordon & Betty Moore Foundation.

The Nocturnists is supported by The California Medical Association and donations from listeners like you.

Host: Emily Silverman, MD

Uncertainty Correspondent: Alexa Miller

Series Illustrations by Eleni Debo

Today, we explore the paradox of mortality: something both certain and utterly unknowable. Through a haunting parable from Ursula K. Le Guin and stories from doctors and loved ones, we hear what happens when people try to plan for death—or avoid it. A daughter processes her mother’s calm decision to pursue assisted dying. A physician grapples with an ambiguous advance directive. A neurointensivist weighs the line between hope and false hope. What do we do when clear answers are impossible? And what happens when our attempts to control death only bring more suffering?  And in the midst of all this uncertainty, how do we find peace?

Find show notes, transcripts, and more at thenocturnists.org, and subscribe to our substack.

The "Uncertainty in Medicine" series is generously funded by the ABIM Foundation, by the Josiah Macy Jr. Foundation, and the Gordon & Betty Moore Foundation.

The Nocturnists is supported by The California Medical Association and donations from listeners like you.

Host: Emily Silverman, MD

Series Illustrations by Eleni Debo

Today, we step inside the studio of visual artist Leila Simon Hayes, whose bold, shape-driven designs are born from a process rooted in imperfection, intuition, and trust. Through her story, we explore how Leila’s creative practice helped her navigate decades of chronic pain and medical dismissal, eventually leading her to healing not through certainty, but through listening—both to her art and her body. Her journey invites us to reconsider our own relationship with uncertainty, and to ask: what happens when we stop demanding answers and start embracing the unknown?

Find show notes, transcripts, and more at thenocturnists.org, and subscribe to our substack.

The "Uncertainty in Medicine" series is generously funded by the ABIM Foundation, by the Josiah Macy Jr. Foundation, and the Gordon & Betty Moore Foundation.

The Nocturnists is supported by The California Medical Association and donations from listeners like you.

Host: Emily Silverman, MD

Uncertainty Correspondent: Alexa Miller

Series Illustrations by Eleni Debo

Today, we explore the hidden layers of communication in medicine—what gets said, what doesn’t, and how uncertainty lives not just in the clinical data, but in the space between people. From a telemedicine encounter with a stubbornly independent patient in the Santa Cruz mountains, to a deeply personal story of navigating breast cancer risk, and finally to the ICU, where one physician is trying to revolutionize how teams talk about the unknown, this episode invites listeners into the gray zones of uncertainty and the doctor-patient relationship.

Find show notes, transcripts, and more at thenocturnists.org, and subscribe to our substack.

The "Uncertainty in Medicine" series is generously funded by the ABIM Foundation, by the Josiah Macy Jr. Foundation, and the Gordon & Betty Moore Foundation.

The Nocturnists is supported by The California Medical Association and donations from listeners like you.

Host: Emily Silverman, MD

Uncertainty Correspondent: Alexa Miller

Series Illustrations by Eleni Debo

Today, we step into the dance studio with improvisational dance artist Chris Aiken, whose work lives at the intersection of uncertainty, movement, and presence. With insights that resonate far beyond the dance studio, Chris explores how attention, poetic instinct, and even failure are essential tools for responding creatively under pressure—much like an ER doctor at a moment of crisis.

Find show notes, transcripts, and more at thenocturnists.org, and subscribe to our substack.

The "Uncertainty in Medicine" series is generously funded by the ABIM Foundation, by the Josiah Macy Jr. Foundation, and the Gordon & Betty Moore Foundation.

The Nocturnists is supported by The California Medical Association and donations from listeners like you.

Host: Emily Silverman, MD

Uncertainty Correspondent: Alexa Miller

Series Illustrations by Eleni Debo

This week, we explore how time and uncertainty are intertwined in the practice of medicine. A toxicologist faces a split-second decision in the ER that could mean life or death for a young patient. A woman with chronic ankle pain spends years searching for answers as dozens of doctors offer snap diagnoses and failed treatments. A rheumatologist navigates the slow, murky waters of autoimmune disease, where diagnosis and treatment often unfold over months or years. And a couple reckons with the long-term implications of a rare and unpredictable heart condition. Through these stories, we see how uncertainty can stretch time out endlessly or collapse it into a single moment and how, in medicine, working with time rather than fighting against it is often the only way forward.

Find show notes, transcripts, and more at thenocturnists.org, and subscribe to our substack.

The "Uncertainty in Medicine" series is generously funded by the ABIM Foundation, by the Josiah Macy Jr. Foundation, and the Gordon & Betty Moore Foundation.

The Nocturnists is supported by The California Medical Association and donations from listeners like you.

Host: Emily Silverman, MD

Uncertainty Correspondent: Alexa Miller

Series Illustrations by Eleni Debo

When a 7.6 magnitude earthquake leveled entire villages in Pakistan, retired U.S. Navy Admiral Mike LeFever was thrust into the heart of the disaster with no playbook and a simple directive: provide humanitarian aid and strengthen U.S.-Pakistan relations. In this episode, LeFever recounts what it was like to lead a massive relief effort in the chaotic aftermath—coordinating aid, rebuilding schools, and navigating diplomacy in a country where his presence was politically charged. As his mission evolved from emergency response to long-term relationship-building, including during the fallout of the Bin Laden raid, LeFever shares hard-won lessons on leadership, humility, and decision-making in extreme uncertainty.

Find show notes, transcripts, and more at thenocturnists.org, and subscribe to our substack.

The "Uncertainty in Medicine" series is generously funded by the ABIM Foundation, by the Josiah Macy Jr. Foundation, and the Gordon & Betty Moore Foundation.

The Nocturnists is supported by The California Medical Association and donations from listeners like you.

Host: Emily Silverman, MD

Uncertainty Correspondent: Alexa Miller

Series Illustrations by Eleni Debo

What happens when doctors have to make life-or-death decisions in an evidence-free zone — and patients are left to navigate the unknown? In episode 5 of “Uncertainty in Medicine", we bring you three gripping, real-life stories: a neurosurgeon weighing impossible risks in the operating room, a palliative care doctor facing a young man’s quiet resolve to die, and a patient whose long-awaited kidney transplant vanishes in a single phone call. These are high-stakes moments where instinct takes over, control slips away, and the only way forward is a leap of faith.

Find show notes, transcripts, and more at thenocturnists.org, and subscribe to our substack.

The "Uncertainty in Medicine" series is generously funded by the ABIM Foundation, by the Josiah Macy Jr. Foundation, and the Gordon & Betty Moore Foundation.

The Nocturnists is supported by The California Medical Association and donations from listeners like you.

This episode is sponsored by a new podcast that fans of the Nocturnists are sure to love. Unleashed: Redesigning Health Care features clinician-innovators who have changed care on the front lines. Their stories, their voices, their ingenuity. Learn more at unleashedpodcast.org.

Host: Emily Silverman, MD

Uncertainty Correspondent: Alexa Miller

Series Illustrations by Eleni Debo

What does uncertainty in medicine have to do with Chernobyl? According to patient safety officer Dr. Ron Wyatt, more than we might think. In the fourth episode of our "Uncertainty in Medicine" series, he draws a chilling connection between one of history’s worst nuclear disasters and the quiet, preventable tragedies that unfold in hospitals every day. In both cases, the warning signs were there. People sensed something was wrong. But no one spoke up—or if they did, no one listened.

Through his work at the Joint Commission, Dr. Wyatt has spent decades investigating sentinel events, the most serious and avoidable medical errors. What he’s found is deeply unsettling: the root causes rarely come down to lack of knowledge. They come from cultures where fear, hierarchy, and silence override curiosity and caution. And time and again, he’s seen how racism and bias magnify that silence. Here, Dr. Wyatt reveals what truly makes healthcare safe—and what has to change to protect every patient, equally.

Quick note: In this episode, Dr. Wyatt mentions his time at The Joint Commission. The correct length of his tenure is 5 years.

Find show notes, transcripts, and more at thenocturnists.org, and subscribe to our substack.

The "Uncertainty in Medicine" series is generously funded by the ABIM Foundation, by the Josiah Macy Jr. Foundation, and the Gordon & Betty Moore Foundation.

The Nocturnists is supported by The California Medical Association and donations from listeners like you.

This episode is sponsored by a new podcast that fans of the Nocturnists are sure to love. Unleashed: Redesigning Health Care features clinician-innovators who have changed care on the front lines. Their stories, their voices, their ingenuity. Learn more at unleashedpodcast.org.

Host: Emily Silverman, MD

Uncertainty Correspondent: Alexa Miller

Series Illustrations by Eleni Debo