This episode, we have a round table discussion with the editorial team of Sam Merriel, Tom Round and Nada Khan. This collection of the BJGP’s top 10 research most read and published in 2025 brings together high-profile primary care research and clinical innovation.
And here are the top 10 most read papers of 2025:
10
Adoption of clinical pharmacist roles in primary care: longitudinal evidence from English general practice
https://doi.org/10.3399/BJGP.2024.0320
9
Factors affecting prostate cancer detection through asymptomatic prostate-specific antigen testing in primary care in England: evidence from the 2018 National Cancer Diagnosis Audit
https://doi.org/10.3399/BJGP.2024.0376
8
Paramedic or GP consultations in primary care: prospective study comparing costs and outcomes
https://doi.org/10.3399/BJGP.2024.0469
7
What patients want from access to UK general practice: systematic review
https://doi.org/10.3399/BJGP.2024.0582
6
Technostress, technosuffering, and relational strain: a multi-method qualitative study of how remote and digital work affects staff in UK general practice
https://doi.org/10.3399/BJGP.2024.0322
5
Antidepressants and risk of postural hypotension: a self-controlled case series study in UK primary care
https://doi.org/10.3399/BJGP.2024.0429
4
Challenges to quality in contemporary, hybrid general practice a multi-site longitudinal case study
https://doi.org/10.3399/BJGP.2024.0184
3
Low-dose amitriptyline for irritable bowel syndrome: a qualitative study of patients’ and GPs’ views and experiences
https://doi.org/10.3399/BJGP.2024.0303
2
Artificial intelligence for early detection of lung cancer in GPs’ clinical notes: a retrospective observational cohort study
https://doi.org/10.3399/BJGP.2023.0489
1
Effectiveness of low-dose amitriptyline and mirtazapine in patients with insomnia disorder and sleep maintenance problems: a randomised, double-blind, placebo-controlled trial in general practice (DREAMING)
https://doi.org/10.3399/BJGP.2024.0173
Transcript
This transcript was generated using AI and has not been reviewed for accuracy. Please be aware it may contain errors or omissions.
Speaker A
00:00:00.480 - 00:01:27.500
Hello and welcome to the BJGP Top 10 podcast.
So this is where we take a closer look at the most read research papers in the BJGP in 2025 and just have a discussion about what they mean for day to day general practice. I'm Nada Khan, one of the associate editors of the Journal.
And in today's episode we'll be exploring some of the themes that really captured attention with the readership, I suppose. And we'll be talking about things like consultation compl complexity and workload pressures.
Some work around diagnostic uncertainty and how to look, look after people with multimorbidity.
And I think we're going to have a discussion a bit more, not just about what these papers found, but maybe a bit about why they resonated and maybe give a bit of editorial feedback around that. And because it's a conversation here between three clinicians as well.
And I'll go around and introduce everyone in a minute, maybe a bit about what they add to the conversations we're already already having in practice and where the gaps still are. And I guess with that we'll be keeping it grounded in the messy reality of today's general practice as well.
So I've introduced myself and I'm joined here by Tom Round and Sam Merrill, who are both also associate editors of the bjgp. But I'll go to Tom first. So, yeah, tell us a bit about who you are and how is your day going?
Speaker B
00:01:27.720 - 00:01:59.550
Great, Nada. Thanks for having me.
So, Dr. Tom Rand, I'm a GP in northeast London and an academic clinical lecturer at King's College, interested in early disease and cancer detection and also health inequality. So, yeah, pretty good. Like everyone, I've got a mild cold at the moment.
I think exactly the same last year when we did this podcast, winter cold season. So I think we're all sort of feeling that a little bit in primary care with flus and other things and staff, you know, so otherwise good.
Looking forward to having really interesting discussion about these papers which are really fascinating and give a real broad breadth of what we do in general practice.
Speaker A
00:02:00.420 - 00:02:07.940
Great. And Sam, we'll go to you and you have some really exciting news in the background as well.
So, yeah, tell us about who you are and what you're up to today.
Speaker C
00:02:08.180 - 00:02:31.770
Thanks, Nad.
I think, yeah, you're alluding to the fact I'm on Puppy alert because our new addition to the family in the winter is keeping us busy and making remote working a challenge. But we're getting through. But yeah, lovely to be with you guys. And I catch up and BJGP and wider podcast audience.
So, yes, I'm a GP working in the Northwest of England and a clinical senior lecture at the University of Manchester.
Speaker A
00:02:32.650 - 00:04:28.830
Brilliant.
Okay, so let's get into the top 10 most read research and published papers of 2025 and I'm going to kick off with number 10 and number 8, just because they're on a sort of related topic. So number 10 is by Michael Anderson and colleagues. Michael's based in Manchester and at lse.
And this paper looks at prescribing, quality in practices and the role of clinical pharmacists as. And I'll just point out that I'll put links to all the papers in the show notes as well.
So this paper looks at the adoption of clinical pharmacist roles in English general practice and asks that question of does bringing pharmacists into the primary care workforce actually lead to improvements? Michael looked at this through a longitudinal approach.
They used national practice level data from 2015 to 2019 and just looked at practices that didn't, didn't have a clinical pharmacist role. And it's really interesting, the results actually.
So, not surprisingly, the proportion of practices with a clinical pharmacist increased from about 3% to over 20% over the course of the study. And the, the team found some really significant improvements across several prescribing indicators.
So things like reductions in total medication costs, better opioid prescribing and prescribing for anxiety meds after pharmacists were implemented in pract, I guess, really it would be interesting to hear your thoughts, Sam and Tom, about what do you think really are the outcomes we want most from clinical pharmacists? And how do you think we should interpret these modest changes at scale?
Because there's a lot else going on in terms of workforce that we need to think about in general practice, like access and continuity and not just meds optimization.
Speaker C
00:04:29.310 - 00:05:41.170
I can talk from practice experience because our clinical pharmacist just left for Canada just in the last month or so. But yeah, it was really interesting, like having him part of the team.
I think in a lot of ways he took a lot of burden off the gps in terms of meds monitoring, meds management, medication reviews. He builds a lot of continuity with a lot of patients because he was doing a lot of checking in.
So in a lot of ways he was quite invaluable member of the team and we have sought a replacement since.
At the same time, you know, there was some, some extra challenges in terms of workload and stuff, because obviously pharmacists have different training and the role of a clinical pharmacist in general practice is relatively new.
So, you know, their approaches to prescribing and, you know, how close you stick to guidelines and how much you adapt for individual patient situations is slightly different. So. Yeah, but I think that was part of sort of feeling a way out with the role.
But it's really noticeable when he's not around because it does affect how the workload flows and how the practice runs and how the patients, you know, interact with the practice. So, yeah, it's been really interesting at the local level.
But, yeah, Michael's study also very interesting to look at the wider picture about how it's affecting quality of care.
Speaker A
00:05:41.730 - 00:05:45.970
And I'll just jump now to number eight, unless, Tom, you want to add.
Speaker B
00:05:45.970 - 00:06:10.770
No, just to say, obviously this, this paper is looking at the macro level up to 2019, so it'd be really interesting what happened since, because we only started having a pharmacist after that point with the induction of ARS roles.
So I think, yeah, further, you know, this is giving a signal, we think that some indices are improving, but also I think it's important to be aligned with our own subjective experience, maybe qualitative and other implementation type research. But overall, I think this trend is a good thing, I think, from my own experience.
Speaker A
00:06:11.570 - 00:07:55.630
Yeah, absolutely.
And then I guess jumping to paper number eight, which was written by William Hollingsworth and his team from Bristol, and this is looking at comparing paramedics in general practice with gps.
And the paper is asking a really practical workforce question, which is, is what happens to patient experience, safety and NHS costs when patients are seen by a paramedic in general practice rather than a gp.
And this team looked at this, they used a prospective cohort study across sites in England and they looked at patients who had an urgent or same day consultation with either a paramedic or a GP and then looked at their outcomes over the next 30 days.
And I guess the headline finding is that really there wasn't a clear difference in patient reported health and well being over 30 days, but there were some differences in that experience right after the consultation. So patients who saw a paramedic said that they were.
Well, they reported lower confidence in their health provision, they felt there are more communication problems and maybe a lower perception of how the practice promotes safety.
And there were fewer subsequent GP appointments in the paramedic group, but there weren't really any GP savings as such that were offset by higher use of other health care professionals. So I guess that you could sort of summarize that by seeing.
Seeing a paramedic might lower GP pressure, but it doesn't necessarily reduce overall NHS costs. So I wonder, yeah, Tom, coming to you, what do you think should really matter when we diversify the workforce?
Do you think it should be workload, cost? Yeah.
Speaker B
00:07:55.710 - 00:09:28.360
Really interesting discussion, isn't it? And we talk about testification, isn't it? Sort of, you know, how do we, you know, how do we help GPs with workload? Workload, sorry.
Fundamentally we need more GPs, don't we? We need to have, you know, we've got high 2,300 to 2,500 patients, sometimes even higher deprived areas.
So fundamentally, I think the workforce, we do need more gps. This also debate, also, you know, obviously there's a slightly toxic now debate about physicians, associates.
You know, from my own viewpoint, you know, undifferentiated initial consultations in primary care are high risk. We know that from all the evidence and the research. So you've got to be very careful about patient select selection and triage for this.
And you can see, I think also this links to. We've got this big increase in the ARS roles, but then we haven't seen that increase in primary care satisfaction.
So I think this comes down to people probably still want to see a GP for certain conditions. How do we get to that right model of MDT working? And I think we do need robust safety evidence.
So this obviously is, you know, it's good study, but it's fairly small scale, probably need larger scale and systematic review evidence about this replacement. You know, what's the safe role? What are the guidelines?
What sort of cases should these people, should other allied healthcare professionals be seeing, particularly for undifferentiated illness?
And going back to the, obviously, the PA debate, we've obviously got the college position that probably PAs should not be seeing undifferentiated illness in primary care. So I think it's a nuanced discussion, but we need better, we need further studies like this to help us decide what we're doing.
Speaker A
00:09:28.760 - 00:09:54.380
Absolutely.
And I think that's really important as the workforce in general practice increases to diversify and policy shifts towards an increasing multidisciplinary team as well. So, yeah, be interesting to see what happens in the future. Really great.
So I'm going to go over to Sam and Sam, you're talking about paper number nine, but, yeah, talk us through this. This is a bit a paper that, you know well, so tell us a.
Speaker B
00:09:54.380 - 00:09:55.820
Bit more about it and your involvement.
Speaker C
00:09:55.820 - 00:09:59.700
In it, first author on a BJGP top 10 paper. I'm very honored.
Speaker B
00:09:59.700 - 00:10:00.460
Congratulations.
Speaker C
00:10:01.020 - 00:13:14.370
Humble to all the readers out there who had looked at it. So this was a study of asymptomatic prostate cancer detection using PSA in primary care in England.
And we used data from what's called the National Cancer Diagnosis Audit. This was the 2018 version.
So we had about a quarter of practices in England participate in the ncda and data was gathered using a sort of standardized template on all the new cancer diagnoses in a practice in 2018. So practices participate were given that list and a template to complete and looking at the record in detail.
So what happened to these patients in the lead up to their diagnosis? Were they seen in general practice? What happened? Were they investigated? Were they referred to?
And it was not screen detected cases for any of these were specifically cases coming through primary care. And the strength of this data set is that we have access to both coded and free text data in the record.
So a lot of large primary care research data sets like CPRD don't have free text data. So it's relying on GP coding, which we know varies between practices. So the big things that this study found we looked at.
So There were nearly 10,000 prostate cancer cases in the entity.
Overall, when we filtered out all the patients who had symptoms recorded at the time of presentation of primary care and the time of diagnosis, we were only left with about 1900.
So the vast majority of men with prostate cancer symptoms were present at the time of diagnosis, which conflicts somewhat with existing literature out there, the quality of which is pretty variable and often not great. So that was one interesting finding.
In terms of the differences between practices for asymptomatic prostate cancer detection and PSA testing, there's huge variation, something like 14 fold difference between the practices picking up the most men through asymptomatic PSA testing and the practice picking up the least.
And we didn't see any obvious GP practice level factors, so it didn't matter about geography, list size, number of GPs, cough outcomes, none of that seemed to make any difference.
There were patient level factors, so older men less likely picked up through that route, which kind of makes sense because symptoms are much more common in men as they get older. And PSA testing, the benefit is less generally depending on their general health, so it might be done less often. So that makes sense.
Men from deprived areas were less likely to be diagnosed through this route, which we know there are significant inequalities for men deprived regions in terms of prostate cancer outcomes. Not Just PSA testing, but stage of diagnosis, treatment outcomes, we need to do better with that group.
And interestingly, white men were less likely to be diagnosed through this route. Even though the sort of stereotypical person being, coming in, asking for a PSA test when there are no symptoms and maybe a low risk is a.
Is an older, wealthy white male, they were less likely to diagnose through this route, which. That was an interesting finding. Yeah. So really interesting study.
Obviously grabbed some interest and is a very, very, very topical issue at the moment with the NSCS recommendation that's out for consultation. And I think, you know, we still got to watch this space because I think there's going to be more coming in the year's ed.
Speaker A
00:13:15.170 - 00:13:42.330
Yeah, really super topical, Sam. And just to point out, we did record a podcast talking about this paper in more detail, if anyone wants to listen to that.
Tom, you work a lot in cancer diagnosis in that sort of world. I mean, obviously brilliant work from Sam and his colleagues, but I just wanted to know what your thoughts were.
Just reflecting on this paper in terms of sort of the wider policy discussions and discussions around the future of prostate cancer screening.
Speaker B
00:13:42.330 - 00:14:36.520
Yeah, yeah. So I think it's very topical, isn't it? There's lots of. In the press around, you know, should we be doing PSA testing?
So we currently got a slightly...