“Have you not done tormenting me with your accursed time?“ Senior scientists Vladimir and Estragon are waiting quite a while for a clot to form in their tube. How should you react to prolonged clotting times? We cover an approach to prolonged PT and aPTT, as well as discuss the mechanism of common anticoagulants and their impact on these basic tests.  

Timestamps
00:00 - Intro
01:22 - Episode 2 Recap 
03:13 - Why clotting times prolong 
05:38 - Short clotting times 
07:00 - Platelets and clotting times
08:00 - Introduction to Anticoagulants
10:25 - Unfractionated Heparin
17:04 - Low Molecular Weight Heparins
20:20 - Fondaparinux
21:37 - Vitamin K "Inhibitors"
27:55 - Direct Oral Anticoagulants
33:04 - Anticoagulants Recap
34:10 - An approach to long clotting times
35:58 - Cases
45:45 - Takehomes

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

It is a truth universally acknowledged that a JMO in possession of a coagulation tube will underfill it. But why should it matter?! In this episode, we review the principles behind the two most important coagulation screening tests (The PT and the aPTT) as well as follow the journey of that precious citrated sample through the lab. By the end, you’ll know enough to at least feel guilty when you still send that half filled tube down the chute at 3am

Timestamps:
00:00 - Introductions
01:40 - Clinical Case
03:29 - Development of coagulation testing
06:05 - Why you need to fill the tube
09:40 - Removing platelets
13:30 - Coagulation Profile and the INR
14:51 - The PT
20:32 - The aPTT
27:00 - Summary

31/5/25 - Just a note that we remastered the audio so this episode sounds much more in line with our current ones - the content hasn't changed however 

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Surely it's just clot or no clot right? Join your intrepid guides Nick, Cale and Bashar as we help you master the med school coagulation cascade and its relevance (or lack of) to laboratory testing of haemostasis. 

Wait what’s that? Everything you’ve been taught so far is an irrelevant lie? Bring yourself up to speed with the cellular model of coagulation and learn what really happens to make that clot appear

Timestamps
00:00 - Introduction to Bloody Minded Podcast 
02:57 - Episode Introduction
03:40 - What's the point?
04:35 - The coagulation cascade
07:00 - Common pathway
13:25 - Factor 13
14:10 - Extrinsic pathway
18:39 - Intrinsic pathway
23:58 - Why the classical model is broken
26:08 - Cellular model of coagulation
30:22 - Summary 

31/5/25 - Just a note that we remastered the audio so this episode sounds much more in line with our current ones - the content hasn't changed however

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Optional Introductions - Skip to Episode 1 if you're after content

We're excited to launch Bloody Minded - a haematology podcast for those who want an extra little drop of knowledge no matter where you are in your medical journey. Learn a little bit about your hosts and how we'll be formatting this show

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au