Bloomberg Businessweek

Vir Biotechnology Vir is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. The company on Monday announced new data from the ongoing Phase 1 clinical trial of VIR-5500, a prostate-specific membrane antigen (PSMA)-targeting, PRO-XTEN dual-masked T-cell engager (TCE) being evaluated in patients with advanced metastatic castration-resistant prostate cancer (mCRPC) who have progressed after multiple lines of therapy. These data suggest that VIR-5500 monotherapy is well tolerated and exhibits promising anti-tumor activity.

Marianne De Backer, Ph.D., the CEO at Vir Bio, discusses the progress being made with the firm's leading treatments, the runup in its share price thus far in 2026, and why partnerships are key to advancing Vir's impact. Dr. De Backer speaks with Carol Massar and Tim Stenovec on Bloomberg Businessweek Daily.

See omnystudio.com/listener for privacy information.

'Bloomberg This Weekend' features unique conversations on business, news, lifestyle and culture. Join David Gura, Christina Ruffini and Lisa Mateo Saturdays and Sundays for discussions with business leaders, lawmakers and cultural icons.  

Watch the show LIVE on Bloomberg Television from 7AM-10AM Eastern Time.   
Listen to the show LIVE on Bloomberg Radio from 7AM-10AM Eastern Time.   

Listen to the Podcast for the best conversations from the show.   
Subscribe on Apple:
https://podcasts.apple.com/us/podcast/bloomberg-this-weekend/id1878739308
Subscribe on Spotify:
https://open.spotify.com/show/5DQ8CEg9LeS1xGJSaxt47l

See omnystudio.com/listener for privacy information.

The US and Israel began striking targets across Iran, with President Donald Trump urging Iranians to overthrow the government in a conflict that threatens to spiral across the oil-rich Middle East.   

“The hour for your freedom is at hand,” Trump said, addressing Iranians in a video posted on Truth Social on Saturday. “When we’re finished, take over your government. It will be yours to take. This will be probably your only chance for generations.”   

The military campaign could be a defining moment for Trump, risking a drawn-out regional war that leads to a surge in energy prices and American casualties ahead of mid-term elections this year. Iran quickly responded by firing missiles on Israel and US bases around the region, and countries in the Persian Gulf closed their airspace.  

Israel’s military said the campaign would target “dozens of military targets,” and Iran media reported strikes on defensive and civilian sites, including more than 50 people dead in a strike on a school in Hormozgan, in the south of the country. Several large explosions were reported in the capital, Tehran.   
Bloomberg's David Gura and Christina Ruffini lead our team coverage in this instant reaction podcast.

See omnystudio.com/listener for privacy information.

Featuring some of our favorite conversations of the week from our daily radio show "Bloomberg Businessweek Daily."

Hosted by Carol Massar and Tim Stenovec

Hear the show live at 2PM ET on WBBR 1130 AM New York, Bloomberg 92.9 FM Boston, WDCH 99.1 FM in Washington D.C. Metro, Sirius/XM channel 121, on the Bloomberg Business App, Radio.com, the iHeartRadio app and at Bloomberg.com/audio.

You can also watch Bloomberg Businessweek on YouTube - just search for Bloomberg Global News.

Like us at Bloomberg Radio on Facebook and follow us on Twitter @carolmassar @timsteno and @BW

See omnystudio.com/listener for privacy information.

The people, companies and trends shaping the global economy.

Watch Carol and Tim LIVE every day on YouTube: http://bit.ly/3vTiACF.
President Donald Trump directed US government agencies to stop using Anthropic PBC’s products, capping a feud between the artificial intelligence giant and the Pentagon over safeguards on its technology.

Trump said Friday that there would be a six-month “phase out period” for agencies including the Defense Department that are using Anthropic’s products.
“The Leftwing nut jobs at Anthropic have made a DISASTROUS MISTAKE trying to STRONG-ARM the Department of War, and force them to obey their Terms of Service instead of our Constitution,” the president posted on social media. “Therefore, I am directing EVERY Federal Agency in the United States Government to IMMEDIATELY CEASE all use of Anthropic’s technology.”
Spokespeople for Anthropic didn’t immediately respond to requests for comment.

Hegseth had given Anthropic until 5 p.m. on Friday to allow the Pentagon to use the Claude chatbot for any means necessary, within legal limits. The company had insisted that Claude not be used for mass surveillance against Americans or in fully autonomous weapons operations.

Trump’s decision will send a shockwave through Silicon Valley, where tech firms have invested billions of dollars on artificial intelligence and are weighing how best to handle federal government contracting. The move takes aim at a company that’s leading development of AI, a centerpiece of Trump’s economic agenda.

Today's show features:

• Bloomberg News Reporter covering technology and national security Katrina Manson, on President Donald Trump directing US government agencies to stop using Anthropic's products due to a feud over safeguards on its technology
• Robert Reffkin, Founder, Chairman and CEO of Compass International Holdings, and Varun Krishna, President and CEO of Rocket Companies, on a three-year strategic alliance aimed at expanding home listing inventory to create an enhanced affordable home buying and selling experience for American families
• Luis von Ahn, Co-Founder, Chairman, President & CEO of Duolingo, on earnings and the struggles of the language learning platform in the era of AI-related disruption
• Bloomberg News Senior Editor, Equities Americas Eric Weiner, recapping the worst trading month since March 2025

See omnystudio.com/listener for privacy information.

February is American Heart Month, known as a critical time for bringing increased attention to cardiovascular health and the prevention of heart disease, which is the leading cause of death in the US. Women are particularly vulnerable to cardiac health threats spanning biological, clinical and healthcare system factors that contribute to underdiagnosis, delayed treatment, and worse outcomes compared to men.

Dr. Joy Gelbman, Associate Professor of Medicine at Weill Cornell Medicine as well as a board-certified cardiologist, is well-versed in the unique challenges facing women when it comes to their cardiac health. She breaks down specific sex-specific risk factors, differing disease presentation and pathophysiology, as well as the experience disparities in treatments and outcomes. Dr. Gelbman speaks with Carol Massar and Tim Stenovec on Bloomberg Businessweek Daily.

See omnystudio.com/listener for privacy information.

The people, companies and trends shaping the global economy.

Watch Carol and Tim LIVE every day on YouTube: http://bit.ly/3vTiACF.

Jack Dorsey’s Block is cutting 4,000 employees, reducing its workforce by nearly half as the financial technology firm places a bet on artificial intelligence changing the future of labor productivity.

Block has been restructuring its business model and staffing since 2024 as the company’s stock has lagged. At the same time, the company has invested heavily in artificial intelligence tools to run more efficiently, including building its own tool called Goose.
The reduction in force, which was announced in a shareholder letter on Thursday, comes after rolling job eliminations that have often been tied to annual performance reviews.
The move by Block is the latest indication of the havoc that new AI tools are wreaking on the economy and financial markets.

In the shareholder letter, the company highlighted strong financial performance over 2025 including gross profit growth that more than doubled from the first quarter to the fourth quarter.

Dorsey, the company’s co-founder, touted how the company has reignited growth of users of its peer-to-peer payments app Cash App, scaled its lending products and accelerated Square gross payment volume. Block reported gross profit of $10.36 billion in 2025, up 17% year-over-year.

Today's show features:

• Bloomberg News Fintech and Crypto Reporter Emily Mason on Block's massive staff cuts
• Chris Miller, Professor of International History at The Fletcher School at Tufts University, on the geopolitical forces shaping the global ecosystem for semiconductors
• Steven Dickens, CEO and Principal Analyst of HyperFRAME Research, with Nvidia earnings analysis and a lookahead to CoreWeave earnings after the bell
• Bloomberg News National Security Reporter Jaime Tarabay on Hillary Clinton’s closed-door testimony related to her connections to the late Jeffrey Epstein, and allegations that the Department of Justice withheld some files in the Epstein case due to an abuse claim against President Trump

See omnystudio.com/listener for privacy information.

The people, companies and trends shaping the global economy.

Watch Carol and Tim LIVE every day on YouTube: http://bit.ly/3vTiACF.

Nvidia Corp., the world’s most valuable company, gave another bullish quarterly revenue forecast, signaling that the massive build-out of AI computing remains on track.
Fiscal first-quarter sales will be about $78 billion, the chipmaker said in a statement Wednesday. That compares with an average Wall Street estimate of $72.8 billion, according to data compiled by Bloomberg.

“Our customers are racing to invest in AI compute — the factories powering the AI industrial revolution and their future growth,” Chief Executive Officer Jensen Huang said in the statement.
The outlook helped soothe concerns about a bubble in AI investments. Huang has repeatedly downplayed fears that the run-up in spending on artificial intelligence hardware isn’t sustainable. He argues that it will take years to replace the world’s installed base of older computers with machines that offer a leap forward in productivity.
But some investors had grown weary of that optimism and traded out of stocks like Nvidia. Wednesday’s report provides some evidence that near-term worries may be overblown.

Today's show features:

• Bloomberg Tech Co-Host Ed Ludlow, and Jay Goldberg, Senior Analyst, Semiconductors & Electronics with Seaport Research Partners, break down Nvidia’s earnings report and outlook
• Bloomberg Intelligence Senior Global Head of Technology Research Mandeep Singh reacts to quarterly earnings from Nvidia and Snowflake, and Bloomberg Intelligence Senior Technology Analyst Anurag Rana with analysis of earnings from Salesforce and the broader disruption to software companies amid concerns that AI will erode demand
• Libby Cantrill, Managing Director and the head of public policy for PIMCO on market reverberations following President Donald Trump’s State of the Union address
• Bloomberg News Miami Bureau Chief Dan Cancel on the report of Cuban forces killing four people who opened fire from a speedboat with Florida tags

See omnystudio.com/listener for privacy information.

Shares of MercadoLibre fell after fourth-quarter net income missed analysts’ estimates as the company continued to invest heavily in its main business lines. MercadoLibre posted $559 million in net income, below the average forecast for $596 million, according to data compiled by Bloomberg. However, the company posted a 45% year-on-year increase in net revenue to $8.8 billion, beating consensus analyst estimates of $8.5 billion, as customers took advantage of free shipping perks in Brazil and piled into MercadoLibre’s credit offerings. That marks its 28th consecutive quarter of annual growth above 30%.

Martin de los Santos, the CFO of South America's largest company, discusses quarterly earnings and the e-commerce giant's continued efforts to scale its fintech platform, Mercado Pago. Martin speaks with Carol Massar and Tim Stenovec on Bloomberg Businessweek Daily.

See omnystudio.com/listener for privacy information.

The Jel Sert Company is a family-owned business that has been at the forefront of innovation in the food and beverage industry since 1926. Jel Sert's products include dessert mixes, drink mixes, and freezer bars, and are made exclusively in West Chicago, Illinois.

Ken Wegner is President of The Jel Sert Company. The grandson of Jel Sert founders Charles and Lillian Wegner, Ken grew up in the business and has worked at the company since 1985, helping steward beloved brands while expanding Jel Sert’s community impact, and growing its workforce to more than 1,400 employees. He discusses the firm's recent expansion within West Chicago, as well as how real-time searches and social data from platforms like TikTok are guiding new flavor development and brand partnerships for Jel Sert. Ken speaks with Carol Massar and Tim Stenovec on Bloomberg Businessweek Daily.

See omnystudio.com/listener for privacy information.