One of the strangest and most disconcerting things about the COVID 19 pandemic has been the story of long COVID.

Many COVID long-haulers  have continued experiencing cognitive symptoms long after their initial COVID infection — loss of attention, concentration, memory, and mental sharpness — what scientists are calling "brain fog".  For some patients, the condition is so serious that it can be impossible to go back to their pre-COVID lives.

Today’s guest, actually had an early intuition that COVID-19 could trigger a neurological health crisis.

Michelle Monje is a pediatric neuro-oncologist here at Stanford who treats kids with serious brain cancers. She also runs a neuroscience research lab that studies how the brain develops during early life. For the past decade, she has been focused on how chemotherapy triggers a cascade of inflammation in the brain that leads to so called “chemo-fog” — a very similar set of symptoms that we now see in many people with long covid.

In this episode, Monje helps us understand what brain fog is, what seems to be causing it, and how her team and others are trying to develop treatments that could help with other conditions linked to inflammation in the brain, such as chronic fatigue syndrome.

References

• Fernández-Castañeda A, Lu P, Geraghty AC, et al. (Iwasaki A, Monje M) Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell. 2022;185(14):2452-2468.e16. doi:10.1016/j.cell.2022.06.008
• Monje M, Iwasaki A. The neurobiology of long COVID. Neuron. 2022;110(21):3484-3496. doi:10.1016/j.neuron.2022.10.006

Read more about Monje's work

• One of Long COVID’s Worst Symptoms Is Also Its Most Misunderstood (The Atlantic)
• Brain fog after COVID-19 has similarities to ‘chemo brain,’ Stanford-led study finds (Stanford Medicine)
• In ‘chemo brain,’ researchers see clues to unravel long Covid’s brain fog (STAT News)
• Even Mild Covid-19 Can Cause Brain Dysfunction And Cognitive Issues (Forbes)

Episode Credits
This episode was produced by Michael Osborne, with production assistance by Morgan Honaker, and hosted by Nicholas Weiler. Art by Aimee Garza.

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