How wisdom is defined and measured in the laboratory, the biology of wisdom, its dynamic relationship with culture, wisdom and aging, wisdom and health, and how we might build wiser societies. THis animation is based on "The New Science of Practical Wisdom" published by Johns Hopkins University Press in the journal Perspectives in Biology and Medicine. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 35488]

Millions of Americans have difficulties with their physical functioning. Dr. Karunesh Ganguly explores the Brain-Computer Interface (BCI). The concept of bio-interactive neural interfaces sates to the early 20th century with successes like cochlear implants, deep brain stimulation and responsive stimulation. He is now working on neural interfaces for communication and movement by working to translate neural engineering based approaches into treatments for those with impaired function. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 35242]

Dr. Aimee Kao looks at recent news in Alzheimer's Disease therapeutics including drugs in development and the potential of stem cells and genome editing. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 35238]

Recently, some scientists have asked whether neural organoids will ever be conscious, and have wondered about the ethical implications of this possibility. Meanwhile, some philosophers have argued that neural organoids are miniature versions of “brains in vats.” Evan Thompson feels that both scientist and philosophers should shift their thinking. He argues that the minimal instantiation of sentience is organismic - not just neuronal, and that conscious processes of moral interest require embodiment and the capacity to suffer.

Series: "Stem Cell Channel" [Health and Medicine] [Humanities] [Show ID: 35248]

What defines consciousness? Can it develop in a petri dish? Patricia Churchland reviews the current state of brain organoid research and shares her views on how conciseness and physical structures within the brain intersect. She also cautions the media on the tendency to "over hype" new research advances. Series: "Women in Science" [Health and Medicine] [Humanities] [Show ID: 35247]

As brain organoids become more widely used in research, concerns about the development of consciousness arise. Christof Koch discusses how we determine and define consciousness and how we look for the underlying physical signatures of consciousness. Series: "Stem Cell Channel" [Health and Medicine] [Humanities] [Science] [Show ID: 35246]

The study of brain organoids is leading to a better understanding of human development and potential therapies for neurological disorders. Yet when people hear the phrase "brain in a dish" it instantly brings to mind the stuff of science fiction - labs full of sentient brains thinking and plotting. Alysson Muotri explains why these organoids should not called "brains in a dish" and how they are being used to explain human processes previously inaccessible to study. While underscoring scientific value of these organoids, he also raises the question of what ethical questions demand an answer as the technology improves. Series: "Stem Cell Channel" [Health and Medicine] [Humanities] [Show ID: 35245]

David M. Holtzman, MD of the Washington University School of Medicine discusses the mechanisms underlying neurodegeneration and how microglia and specific microglial genes such as TREM2 influence neurodegeneration in the setting of Aβ and tau pathology. Learn how this line of study may lead to new therapeutics and diagnostic testing for Alzheimer's disease. Series: "Brain Channel" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 35262]

Worldwide 50 million people live with dementia. By 2040 over 70% of them will be living in the developing world. Dr. Shamiel McFarlane explores the social and economic cost of dementia around the world.

Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 34779]

There are modifiable behaviors that may reduce the risk factor of Alzheimer's: vascular disease, sedentary lifestyle, depression/stress, diet factors and alcohol. Kaitlin Casaletto talks about the benefits of an active lifestyle and proper nutrition. Then Dr. Joanna Hellmuth looks at how to decode direct-to-consumer interventions - dietary supplements - and the rise of pseudo-medicine for dementia. She explains that supplements may or may not be safe and that manufacturers can make broad claims without supporting evidence. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 35136]