Dr. Casey Grover explores the history, neuroscience, and treatment approaches for methamphetamine use disorder, highlighting how methamphetamine releases more dopamine than any other known substance.

• Methamphetamine was widely used during World War II by German, Japanese, and Allied forces to enhance performance
• Modern meth production shifted from ephedra to P2P method, creating cheaper, more potent meth with worse psychiatric effects
• Meth causes dopamine release up to 1,400 ng/dL of dopamine compared to cocaine (400), sex (200), and food (150), severely damaging reward centers
• Many methamphetamine users have undiagnosed ADHD and are inadvertently self-medicating
• Effective medications include bupropion, topiramate, atomoxetine, viloxazine, guanfacine, and mirtazapine
• Contingency management (reward-based incentives) shows significant efficacy for methamphetamine addiction treatment
• Combination therapies using bupropion with naltrexone show promise for reducing meth use
• Treating underlying mental health conditions and providing housing/social support remains essential for recovery

To contact Dr. Grover: [email protected]