Blood Podcast

CD8+ T-cell differentiation and treatment response in AML; ATM germline pathogenic variants affect cancer outcomes in ataxia-telangiectasia; efficacy of a selective menin-KMT2A inhibitor in KMT2A- and NPM1-altered leukemias

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In this week's episode we’ll discuss how CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia; learn more about the effect of ATM germline pathogenic variants on the outcomes in children with ataxia-telangiectasia and hematological malignancies; and discuss the preclinical efficacy of a potent, selective menin-KMT2A inhibitor JNJ-75276617 in KMT2A- and NPM1-altered leukemias.

Featured Articles:

  • CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia
  • ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological
    malignancies
  • Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in
    KMT2A- and NPM1-altered leukemias


...more
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Blood PodcastBy American Society of Hematology
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