In Part 1 of this topic, Emily Gutowski interviews Dr. Zaid Almarzooq, cardiology fellow at Brigham and Women's Hospital, about the evaluation of a patient with chest pain. They discuss a case of a woman in the emergency room with chest pain,  important questions to ask on history, physical exam findings to look out for, as well as the differential diagnosis for chest pain. In Part 2, the topic will conclude with a discussion about diagnostic testing, management, and clinical pearls.