It’s rare to find a televised female friendship that can deal with dead husbands, car crashes and other wild plot twists the way Christina Applegate and Linda Cardellini’s “Dead to Me” characters do. Through years of filming the tragicomedy, the two actors learned to deeply trust each other. When Applegate was diagnosed with multiple sclerosis while filming the last season, their bond only intensified.

In this episode of “The Envelope,” Applegate and Cardellini laugh, sob, describe why they love each other and ponder the possibility of working together again. They also discuss the importance of flawed-mom characters and recall how they were allowed to improvise lines until things got way too weird.

To read a full transcript of this interview, please visit the episode page at latimes.com.