Section Chief of Reproductive Endocrinology and Infertility at Cleveland Clinic's Fertility Center, Mindy Christianson, MD, MBA, joins the Cancer Advances podcast to discuss uterine-focused fertility preservation. Dr. Christianson talks about the uterine damage that can be caused by pelvic radiation and explains uterine transposition as a solution. During the episode, Dr. Christianson provides details on the complex surgery, its success stories, and emphasizes the significance of a comprehensive, multidisciplinary approach to fertility preservation.

Jacob Miller, MD, a Radiation Oncologist at Cleveland Clinic, joins the Cancer Advances podcast to share his insights on nasopharyngeal carcinoma (NPC) screening and his trial presented at the American Society of Radiation Oncology (ASTRO) 2023 Annual Meeting. NPC is rare in the United States but prevalent in Southern China, primarily caused by the Epstein-Barr virus (EBV). Listen as Dr. Miller explains his screening trial that resulted in earlier-stage diagnoses and improved outcomes, as well as lessons from this research that may inform screening strategies for other cancers.

The Cancer Advances podcast is joined by Shahzad Raza, MD, a hematologist at Cleveland Clinic Cancer Center, discussing eye toxicities linked to cancer treatments. Listen as Dr. Raza talks about his study examining real-world experiences compiling eye toxicities from several anticancer drugs. During the podcast, he emphasizes the importance of the early involvement of ophthalmologists in patient care and incorporating ophthalmology exams in clinical trials.

Emre Gorgun, MD, colorectal surgeon and Vice Chair of Colorectal Surgery at Cleveland Clinic, joins the Cancer Advances podcast to talk about his study from Digestive Disease Week (DDW) on predicting complete responses to total neoadjuvant therapy (TNT) in patients with locally advanced rectal cancer. Listen as Dr. Gorgun share insights on success rates of TNT, the factors influencing complete response, patient surveillance, and the potential use of immunotherapy.

Faiz Anwer, MD, a hematologist at Cleveland Clinic Cancer Center, joins the Cancer Advances podcast to discuss CRISPR, a gene-editing technology. Listen as Dr. Anwer highlights CRISPR's advantages over traditional cellular therapies, the challenges of off-target effects, and its future in solid tumor treatment.

Medical Oncologist and Co-Director of the Lung Cancer Program at Cleveland Clinic, Nathan A. Pennell, MD, PhD joins the Cancer Advances podcast to discuss the study he and his team conducted exploring the potential benefits of transitioning from single-gene testing to next-generation sequencing (NGS). Listen as Dr. Pennell explains the pivotal role genomic testing has in treating lung cancer and the barriers to widespread NGS testing.

Radiation Oncologist and Co-Director of the Comprehensive Breast Cancer Program at Cleveland Clinic, Chirag Shah, MD, joins the Cancer Advances podcast to discuss his study on the innovative use of CPAP (Continuous Positive Airway Pressure) machines in combination with radiation therapy. Listen as Dr. Shah explains how using CPAP machines in radiation therapy has been shown to reduce radiation-related toxicities in breast and lung cancer patients.

Ruth Keri, PhD, Associate Director for Basic Research at the Case Comprehensive Cancer Center and Professor of Cancer Biology at Cleveland Clinic, joins the Cancer Advances Podcast to talk about her research on a promising new target for treating triple-negative breast cancer, YES1 inhibitors. Listen as Dr. Keri shares the potential of YES1 inhibitors in improving the effectiveness of chemotherapy and the clinical trials that are underway to assess the safety and effectiveness of these inhibitors.

Suneel Kamath, MD, a hematologist and medical oncologist at Cleveland Clinic Cancer Center, joins the Cancer Advances podcast to discuss his research from the American Society of Clinical Oncology (ASCO) 2023 annual meeting on the metabolomic differences between young onset colorectal cancer (yoCRC) and average onset colorectal cancer (aoCRC). Listen as Dr. Kamath talks about the challenges associated with early detection, the evolving landscape of screening guidelines, potential contributing factors to the rise of yoCRC, and the role of metabolomics in unraveling the complexities of colorectal cancer.

We kick off Breast Cancer Awareness Month with radiologist Laura Dean, MD, who discusses the incorporation of artificial intelligence (AI) into mammography for breast cancer screening and detection. Listen in as our host, Dr. Dale Shepard, talks with Dr. Dean about the new AI algorithms that have improved the accuracy of mammogram interpretations. Dr. Dean explains digital breast tomosynthesis (3D mammography), the benefits of AI in reducing callback rates, and more.