We welcome Dr. Danielle Bowen Scheurer to our conversational team this week She’s a hospitalist at the Medical University of South Carolina and an associate editor of Physician’s First Watch.

Our guest is Dr. Deepak Bhatt, who has just published some reassuring results on omeprazole’s putative interaction with clopidogrel in the New England Journal of Medicine.

If you’d like to suggest topics or ways to improve this podcast, we’re all ears. Drop me a line at [email protected] — thank you.

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Welcome back. We take a look this week at a study from Iceland that looks at whether estimated glomerular filtration rates have a role in estimating cardiovascular risk. Our interview is with Cambridge University’s Dr. Emanuele Di Angelantonio.

Your comments are welcome, both here and to my email address: [email protected].

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Prof. Martin Dennis chats with us about his latest trial, comparing the utility of thigh- versus below-knee-length stockings for patients immobilized after stroke. The latest results show the superiority of thigh-length stockings, but at the further risk of skin breaks in these vulnerable patients. Taken together with the results of his earlier work, at the very least the use of below-knee-length compression stockings — now widely used in patients undergoing surgery — must be called into question.

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Answer: Osteoarthritis. Two are nostrums and the other is a disease, but the nostrums have no appreciable effect — on osteoarthritis at least. We discuss a BMJ meta-analysis that uses novel methods to prove the point.

The good news is that neither chondroitin nor glucosamine is dangerous, but the bad news is that we spend so much hoping that this is the right combination to alleviate arthritic pain.

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We’re not talking about philosophy here, but practical clinical approaches to making sure your patients understand what they’re agreeing to, and have the information to ask the right questions before they sign that form.

It’s podcast 100. I’m always looking for ways to make this useful, and if you have any reactions, please drop a line to [email protected]. Thank you!

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It was thought that the increased risk among blacks undergoing stenting had to do with factors such as comorbid conditions and socioeconomics. But in a study in Circulation, their rate of stent thrombosis was higher than non-blacks, even after adjusting for those factors (and despite the fact that as a group, black were more adherent to their clopidogrel regimens).

We discuss things with the paper’s senior author, Dr. Ron Waksman.

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Our interview this week is with a research nutritionist whose BMJ meta-analysis found a 14% reduction in risk for type 2 diabetes among those with the highest intake (versus those with the lowest) of leafy green vegetables. It’s a meta-analysis, and not a randomized controlled trial, and it’s interesting. Listen in.

We’re off next week, so I’ll see you again in early September.

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Vena cava filters, often meant to be permanent, can actually lose a strut or two. And it’s not as rare an occurrence as you might think. Our conversationalist found it happens about 15% of the time with a certain brand of filter. The FDA has announced that it’s starting its own studies of the problem. Listen in.

If you see something during the week that you’d like me to devote an interview to, please let me know. My email is [email protected]. I’d love to have your suggestions.

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What becomes of children who survive cancer treatment and enter their reproductive years? Would their attempts to have children end in a higher-than-normal rate of stillbirths and miscarriages? Apparently not.

It turns out the major concern is with women who’ve undergone pelvic irradiation before menarche. That treatment seems to hobble uterine development, but not irretrievably. For their part, boys who’ve had gonadal irradiation seem not to place their offspring at higher risk for adverse birth outcomes.

Our conversation is with the senior author on a Lancet paper from last week investigating these effects.

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This week’s interview is with the editorialist commenting on an exciting Lancet paper. The writer, Dr. Gbenga Ogedegbe, says that the work, in which patients with uncontrolled hypertension titrated their own medications according to prespecified rules, could change how clinicians manage uncomplicated hypertension. From his base at New York University School of Medicine, Dr. Ogedegbe sees promise — if the costs are right. Listen in.

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