A study in the journal Nature has uncovered a significant link between the brain's natural lithium levels and Alzheimer's disease (AD). After analyzing 27 different metals in post-mortem human brain tissue, researchers found lithium was the only one significantly reduced in individuals with both mild cognitive impairment (MCI) and AD. The research also showed that amyloid-β plaques, a key marker of AD, trap lithium, which further lowers its availability for use by brain cells.

To confirm this link, scientists conducted experiments on mouse models. They found that reducing the brain's lithium levels by roughly 50% caused an acceleration of AD-like pathology, including increased amyloid-β and phospho-tau deposits, greater neuroinflammation, and a more rapid decline in cognitive function. These effects appear to be driven, at least in part, by the over-activity of a kinase known as GSK3β.

As a potential therapeutic strategy, the team tested a specific salt, lithium orotate (LiO), which is less likely to be sequestered by amyloid plaques. In AD mouse models, low-dose treatment with LiO successfully prevented memory loss and the accumulation of amyloid and tau pathology. The therapy was highly effective, reducing the Aβ plaque burden by about 70% in one model. Furthermore, LiO even reversed age-related memory decline in normal aging mice, pointing to a broader role for lithium in maintaining cognitive health. The findings suggest that a disruption of lithium balance may be a treatable early event in the development of Alzheimer's disease.

Disclaimers

"This information is for educational purposes only and should not be interpreted as medical advice."

"The study discussed was conducted on human post-mortem brain samples and mouse models. Further research may be needed to confirm these findings in human clinical trials."

"Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications. Lithium can be toxic at high doses and should only be used under medical supervision."

"This channel does not provide medical advice."

#Lithium #AlzheimersDisease #NeuroscienceResearch #CognitiveHealth #LithiumOrotate

Aron, L., Ngian, Z.K., Qiu, C., et al. "Lithium deficiency and the onset of Alzheimer's disease." Nature (2025).

A recent network meta-analysis published in the journal

Nutrients systematically compared the effectiveness of seven common nutritional supplements for treating knee osteoarthritis (KOA). The analysis included 39 randomized controlled trials (RCTs) with a total of 4,599 patients. Researchers evaluated the impact of eggshell membrane, vitamin D, Boswellia, curcumin, ginger, krill oil, and collagen against a placebo for improving pain, stiffness, and function. The results showed that compared to a placebo, Boswellia provided statistically significant improvements across all measures, including WOMAC pain (mean difference [MD] = -10.58), stiffness (MD = -9.47), function (MD = -14.00), and VAS pain (MD = -17.26). Bayesian analysis consistently ranked Boswellia as the most likely to be the best option for pain and stiffness relief. Other supplements also showed benefits; krill oil, curcumin, and collagen significantly improved function, while collagen, curcumin, and ginger significantly reduced VAS pain scores. Importantly, no supplement was associated with an increase in adverse events compared to the placebo. The authors conclude that certain supplements, particularly Boswellia, appear to be effective and well-tolerated for managing KOA symptoms.

Disclaimers:

• "This information is for educational purposes only and should not be interpreted as medical advice."

• "The study discussed is a network meta-analysis of randomized controlled trials conducted on humans. Further research may be needed to confirm these findings."

• "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

#Boswellia #Curcumin #Collagen #KrillOil #Ginger

Zhang Y, Gui Y, Adams R, Farragher J, Itsiopoulos C, Bow K, Cai M, Han J. Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis. Nutrients. 2025; 17(15):2547. https://doi.org/10.3390/nu17152547

Alchepharma,Ralph Turchiano,citation,research,study,Knee osteoarthritis,nutritional supplements,Boswellia,curcumin,collagen,ginger,krill oil,eggshell membrane,vitamin D,network meta-analysis,randomized controlled trials,WOMAC pain,WOMAC stiffness,WOMAC function,VAS pain,joint pain relief,osteoarthritis treatment,supplement efficacy,anti-inflammatory supplements

A recent study published in Frontiers in Psychology surveyed 1,082 participants to investigate how food influences sleep and dreams, exploring direct food effects, physiological symptoms (food distress), and altered sleep quality. The study found that 40.2% of participants reported food affecting their sleep, with 24.7% claiming it worsened sleep and 20.1% reporting improvement. Furthermore, 5.5% of participants experienced food-dependent dreaming. The perceived effect of food on dreams was linked to higher nightmare recall and Nightmare Disorder Index scores. Desserts/sweets (31%) and dairy (22%) were most frequently blamed for disturbing dream changes. The study also revealed associations between perceived food-dependent dreaming and food allergies and gluten intolerance, while worse sleep perceptions were tied to lactose intolerance. Importantly, higher Nightmare Disorder Index scores were strongly associated with food allergy and lactose intolerance, with the latter being mediated by the severity of gastrointestinal symptoms. Healthy eating, such as less evening eating, predicted higher dream recall, while unhealthy eating, including gastric symptoms, lower reliance on hunger/satiety cues, and evening eating, predicted nightmares and dream negativity. These findings suggest that food sensitivities, particularly lactose intolerance, can contribute to nightmare prevalence, potentially through gastrointestinal symptoms, opening new avenues for research on food-dependent dreaming and non-pharmacological interventions for sleep disturbances.

Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice." "The study discussed was conducted on humans via an online survey and focuses on perceived effects and associations. Further experimental research is needed to confirm direct causal links between specific foods and dream content." "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications." "This channel is not monetized and does not provide medical advice

#FoodAndDreams #NightmareResearch #LactoseIntolerance #SleepHealth #DietAndSleep

Nielsen T, Radke J, Picard-Deland C and Powell RA (2025) More dreams of the rarebit fiend: food sensitivity and dietary correlates of sleep and dreaming. Front. Psychol. 16:1544475. doi: 10.3389/fpsyg.2025.1544475

Alchepharma,Ralph Turchiano,food sensitivity dreams,dietary correlates sleep,dreaming nightmares,lactose intolerance nightmares,food allergy dreams,gluten intolerance dreams,night eating dreams,evening eating sleep,gastrointestinal symptoms dreams,diet sleep quality,food-dependent dreaming,healthy eating dreams,unhealthy eating nightmares,psychological effects food,sleep disturbances diet,specific food effects dreams,dream recall diet

A recent randomized, placebo-controlled, crossover trial investigated the link between high-dose oral thiamine supplementation and chronic fatigue in 40 patients with quiescent inflammatory bowel disease (qIBD). The study found that while high-dose thiamine (600-1800 mg/day for 4 weeks) significantly reduced fatigue, it did not alter the overall gut microbiota composition or short-chain fatty acid (SCFA) concentrations.

Instead, the study revealed a significant correlation: patients with higher baseline levels of the gut bacteria Faecalibacterium prausnitzii and Roseburia hominis were more likely to respond positively to thiamine treatment. Specifically, Faecalibacterium prausnitzii was more abundant in thiamine responders both before (P=.019) and after (P=.038) treatment. The relative abundance of both Faecalibacterium prausnitzii and Roseburia hominis inversely correlated with improvements in IBD fatigue scores. Of the patients classified as responders (those who decreased their IBD-FQ1 score by 3 or more points), all 17 individuals showed this positive response. Furthermore, Faecalibacterium prausnitzii abundance was significantly greater in these responders compared to nonresponders. These findings suggest that these specific bacteria may serve as markers to predict who will benefit from thiamine for IBD-related fatigue, rather than being directly modified by the thiamine itself.

3. Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice." "The study discussed was conducted on a specific population (patients with quiescent inflammatory bowel disease). Further research may be needed to confirm these findings in other populations." "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications." "This channel is not monetized and does not provide medical advice."

#IBDFatigue #Thiamine #IBD #FaecalibacteriumPrausnitzii #InflammatoryBowelDisease

Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii Abundance Bermúdez-Sánchez, Sandra et al. Gastro Hep Advances, Volume 4, Issue 1, 100533

Alchepharma,Ralph Turchiano,citation,Thiamine inflammatory bowel disease fatigue,quiescent IBD fatigue treatment,Faecalibacterium prausnitzii IBD,Roseburia hominis fatigue,gut microbiota IBD fatigue,vitamin B1 IBD,chronic fatigue IBD,butyrate gut bacteria,gut-brain axis IBD,microbial diversity IBD,thiamine supplementation benefits,Crohn's disease fatigue,ulcerative colitis fatigue,fatigue biomarkers IBD,gut health IBD,Faecalibacterium prausnitzii abundance

Vitamin A5 is a fascinating "new" vitamin that acts as a vital key in your body. It helps activate something called the Retinoid X Receptor (RXR), which is like a central control panel or "master switch" for many important functions. This crucial vitamin comes from certain foods, especially leafy green vegetables. Research suggests that many people in Western countries aren't consuming enough of these foods, leading to a potential Vitamin A5 deficiency. This lack could be a contributing factor to the rising rates of poor mental health and neurological issues. By making sure you get enough Vitamin A5 through your diet, you're essentially providing your body with the right tool to keep these vital systems running smoothly, offering a plausible explanation for why a diet rich in vegetables is so protective against many common diseases.

Disclaimers

"This video shares information for learning only and isn't medical advice." "The science on Vitamin A5 is still growing, and we need more studies in people to fully understand all its effects, especially on the brain."

"Always talk to your doctor or a health expert before changing your diet or taking any new supplements, especially if you have health concerns or take medications." "This channel does not make money from videos and does not give medical advice."

#VitaminA5 #BrainHealth #HealthyEating #MentalWellness #EatYourGreens

Bohn T, Rohn S, Böhm V, Despotovic M, de Lera AR, Krezel W, Kucuk O, Bánáti D, Rühl R. Vitamin A5: Evidence, Definitions, Gaps, and Future Directions. Nutrients. 2025; 17(14):2317. https://doi.org/10.3390/nu17142317

Alchepharma,Ralph Turchiano,citation,research,study,Vitamin A5 benefits,new vitamin discovery,leafy greens brain,healthy diet mental health,RXR activation,retinoid X receptor,neurodegenerative disease prevention,cognitive function diet,what is Vitamin A5,natural brain boost,dietary supplements science,mental clarity food,immune system vitamin,cellular differentiation,chronic disease diet,carotenoids health,future of vitamins,9-cis-beta-carotene

A randomized, double-blind, placebo-controlled trial investigated the sleep-promoting effects of Heukharang lettuce (Lactuca sativa L.) extract in Korean adults aged 30-65 with poor sleep quality (Pittsburgh Sleep Quality Index (PSQI) score > 5). Over four weeks, participants received two capsules daily of either the test extract or a placebo. The study found that the test group showed a greater improvement in global PSQI scores compared to the placebo group (6.48 ± 0.63 vs. 7.41 ± 0.57, p=0.0462). Objective measurements from actigraphy revealed significant improvements in total sleep time (TST) (421.68 ± 13.29 min vs. 386.57 ± 12.27 min, p=0.0023) and sleep efficiency (SE) (83.90 ± 1.60% vs. 81.01 ± 1.50%, p=0.0342) in the test group. Polysomnography (PSG) results also favored the test group, demonstrating higher TST (358.90 ± 19.75 min vs. 322.11 ± 17.66 min, p=0.0457), higher SE (86.86 ± 3.31% vs. 79.60 ± 2.99%, p=0.0182), and lower wake after sleep onset (WASO) (39.26 ± 10.57 min vs. 68.15 ± 9.60 min, p=0.0042). These findings suggest that Heukharang extract can enhance both sleep quality and quantity and is considered safe, indicating its potential as a functional food for improving sleep.

3. Disclaimers:

• This information is for educational purposes only and should not be interpreted as medical advice.

• The study discussed was conducted on Korean adults aged 30-65 with poor sleep quality. Further research may be needed to confirm these findings in other populations.

• Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.

• This channel is not monetized and does not provide medical advice.

• (Remember to include a verbal disclaimer in the video itself.)

#LettuceSleep #HeukharangExtract #SleepQualityImprovement #SleepResearch #FunctionalFood

Son K, Lee M, Bok MK, Hwang KJ, Lim H. Sleep Promoting Effects of Lettuce (Lactuca sativa L.) Extracts in Korean Adults with Poor Sleep Quality: A Randomized, Double-Blind Placebo-Controlled Trial. Nutrients. 2025; 17(13):2172. https://doi.org/10.3390/nu17132172

Alchepharma,Ralph Turchiano,citation,research,study,Pittsburgh Sleep Quality Index (PSQI),total sleep time (TST),sleep efficiency (SE),wake after sleep onset (WASO),Heukharang extract efficacy,sleep disorder natural remedies,sesquiterpene lactones (BSLs),lactucin sleep,lactucopicrin sleep,GABA receptors sleep,subjective sleep quality assessment,objective sleep measures,Korean adults health,sleep duration improvement,non-pharmacological sleep aids

A recent study published in LabMed Discovery investigated the effectiveness of a vitamin D3-loaded nanoemulsion in improving core manifestations of autism spectrum disorder (ASD) in children, compared to a widely available vitamin D3 product. The research involved 80 children with ASD, aged 3 to 6 years, divided into two groups over six months. Group I received an oral vitamin D3-loaded nanoemulsion, while Group II received a marketed oral vitamin D3 product.

Results showed that supplementation with the vitamin D3-loaded nanoemulsion in Group I led to significant elevations in both 25(OH) and 1,25(OH)2 forms of vitamin D3 (P < 0.0001). This group also experienced behavioral improvements, including a reduction in ASD severity (P = 0.0002), an increase in social IQ (P = 0.04), and a rise in total language age (P = 0.0009). In contrast, Group II, receiving the marketed vitamin D3 product, did not show significant adaptive behavioral improvements, despite elevated vitamin D3 levels. The study concludes that the vitamin D3-loaded nanoemulsion offered superior bioavailability and a tangible positive influence on ASD severity, adaptive behavior, fine motor abilities, and language performance.

3. Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice."

"The study discussed was conducted on human participants (children with ASD). While promising, further research may be needed to confirm these findings across broader populations."

"Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

"This channel does not provide medical advice."

#AutismResearch #VitaminD3Nanoemulsion #ASDTreatment #Neurodevelopment #ChildhoodAutism

Study Citation:

Meguid, N. A., et al. (2025). Improved core manifestations of autism following supplementation with vitamin D3-loaded nanoemulsion. LabMed Discovery. doi.org/10.1016/j.lmd.2025.100071.

Alchepharma,Ralph Turchiano,Autism spectrum disorder,vitamin D3 nanoemulsion,core manifestations autism,language performance autism,social IQ autism,adaptive behavior ASD,vitamin D bioavailability,ASD intervention,childhood autism rating scale,Vineland adaptive behavior scale,preschool language scale,25-hydroxycholecalciferol,25-dihydroxycholecalciferol,vitamin D deficiency autism,clinical trial vitamin D,cognitive function autism,motor skills autism

A recent systematic review in the journal Nutrients analyzed 146 studies to evaluate the safety and efficacy of glucosamine and chondroitin in humans. Researchers found that for conditions like osteoarthritis and joint pain, the supplements are generally effective and well-tolerated. Over 90% of the efficacy studies included in the review reported positive outcomes for patients. Similarly, a majority of safety studies (80 out of 107) concluded that the supplements have minimal to no adverse effects, with the most common being mild gastrointestinal complaints. The most frequently studied and effective daily dosages were 1500 mg for glucosamine and 1200 mg for chondroitin, typically taken together in two or three divided doses.

Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice."

"The information presented is from a systematic review of 146 human studies, the majority of which were randomized controlled trials."

"Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

"This channel does not provide medical advice."

#Glucosamine #Chondroitin #Osteoarthritis #JointPain #SystematicReview

Baden KER, Hoeksema SL, Gibson N, Gadi DN, Craig E, Draime JA, Tubb SM, Chen AMH. The Safety and Efficacy of Glucosamine and/or Chondroitin in Humans: A Systematic Review. Nutrients. 2025; 17(13):2093. https://doi.org/10.3390/nu17132093

Glucosamine, Chondroitin, Glucosamine Chondroitin, Osteoarthritis, Joint Pain, Knee Osteoarthritis, Hip Osteoarthritis, Temporomandibular Disorder, Cartilage, Joint Health, Supplement Efficacy, Supplement Safety, WOMAC score, Lequesne Index, Visual Analog Scale, Joint Pain Relief, Anti-inflammatory supplements, Systematic Review, Human Studies, Clinical Trial, Glucosamine d

A recent 6-month study looked at whether taking hawthorn fruit (HF) supplements could improve facial skin and a biological marker of aging called telomere length. They had 36 adults, aged 25 to 75, participate, with some taking a hawthorn fruit powder supplement (900 mg/day) and others taking a dummy pill (placebo). The exciting news is that the group taking hawthorn fruit saw a significant boost in their skin's hydration (how moist and plump it was) compared to the placebo group. Specifically, the hawthorn group's hydration scores went up by 1.71 points on average, while the placebo group's went down by 3.00 points. While there wasn't a big change in overall telomere length, the study found that the improvements in skin hydration were particularly noticeable in people with a specific genetic makeup (those with the "CC" genotype of rs7705526). What's more, the hawthorn group also saw a reduction in wrinkles, while the control group's wrinkles actually increased, especially for those with another specific genetic makeup (the "AA" genotype of rs2853669). These results suggest that adding hawthorn fruit to your routine might help fight skin aging, and it might even work better for some people depending on their genes.

Disclaimers:

"This information is just for learning and shouldn't be taken as medical advice."

"This study was done on adults. More research might be needed to see if these results apply to everyone or if different amounts of hawthorn fruit would have the same effect."

"Always talk to a doctor or healthcare professional before changing your diet, taking new supplements, or changing any treatment plans, especially if you have health issues or are on medication."

"This channel isn't monetized, and we don't give medical advice." (Remember to say these disclaimers in your video.)

Hashtags:

#HawthornForSkin #YouthfulSkin #NaturalBeauty #SkinScience #HealthyAging

Kim M, Baik I. Effects of Hawthorn Fruit Supplementation on Facial Skin Phenotypes and Leukocyte Telomere Length Stratified by TERT Polymorphisms. Nutrients. 2025; 17(12):1983. https://doi.org/10.3390/nu17121983

Search Terms:

Alchepharma,Ralph Turchiano,citation,research,study,Hawthorn skin benefits,younger looking skin,natural wrinkle reduction,anti-aging supplements,hawthorn fruit extract skin,healthy skin diet,genetic factors skin aging,telomeres and skin,what helps wrinkles,best supplements for skin,clear skin tips,natural remedies for dry skin,hawthorn berries benefits,skin health research,how to get glowing skin,research on natural anti-aging,improve skin elasticity

The Liver & Weight Connection: New Curcumin Research Ep. 1246 JUN 2025

Summary

A 12-month, double-blind, placebo-controlled trial has revealed that daily supplementation with 1500 mg of curcumin offers significant benefits for both liver health and weight management in individuals with Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). The study demonstrated remarkable improvements in liver health markers for the curcumin group compared to the placebo group. Specifically, after 12 months, participants taking curcumin had significantly lower liver stiffness (4.2 kPa vs 6.9 kPa) and significantly less liver fat, as measured by the Controlled Attenuation Parameter (223 dB/m vs 292 dB/m). Fatty liver-associated indicators such as the Fatty Liver Index (FLI) and Hepatic Steatosis Index (HSI) also showed significant reductions.

In addition to these direct liver benefits, the curcumin group also experienced significant improvements in body composition. Body Mass Index (BMI) was significantly reduced from the 6-month mark onward. At the end of the study, the median BMI for the curcumin group was 25.97 kg/m², notably lower than the placebo group's 27.70 kg/m². Furthermore, significant decreases in total body fat and waist circumference were observed. The researchers suggest that curcumin's anti-inflammatory and antioxidant properties may underlie these combined benefits, making it a promising adjunctive therapy for managing both liver health and weight.

Disclaimers

This information is for educational purposes only and should not be interpreted as medical advice.

The study discussed was conducted on humans with Type 2 Diabetes and MASLD. Further research may be needed to confirm these findings in other populations.

Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.

This channel does not provide medical advice.

#Curcumin #LiverHealth #WeightLoss #MASLD #BMI

Yaikwawong M, Jansarikit L, Jirawatnotai S, Chuengsamarn S. Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial. Nutrients. 2025; 17(12):1972. https://doi.org/10.3390/nu17121972

Alchepharma,Ralph Turchiano,citation,research,study,Curcumin liver health,Curcumin weight loss,MASLD treatment,hepatic steatosis curcumin,curcumin liver stiffness,curcumin BMI reduction,fatty liver index,FibroScan curcumin,supplements for liver fat,curcumin body fat,clinical trial curcumin liver,antioxidant supplements liver,non-alcoholic fatty liver disease,weight management supplements,liver enzyme improvement,curcumin for metabolic syndrome