The Spanish Flu pandemic of 1918 has in many ways guided the public health, economic, and social responses to the current COVID-19 pandemic. Most of those “lessons learned” proved useful, many perhaps not, and certainly, some have been controversial. This episode examines historical lessons from 1918, how they played out for COVID-19, and how these two pandemics will help us (hopefully) prepare for the next one. (Originally recorded June 24, 2021) Moderator: Ryan Maves, MD, FCCP. Panelists: James Lawler, MD, MPH, FIDSA, and Dale C. Smith, PhD. For more tools to help in the fight against COVID-19, visit CHEST’s COVID-19 Resource Center at chestnet.org/COVID19.