Managing COVID-19 patients and now immunizing the population has been an evolving problem over the last several months. The challenges facing clinicians and leaders have been especially difficult for those in resource-poor and low/middle-income countries. This episode seeks to highlight those issues while discussing opportunities for success in these settings. (Originally recorded February 11, 2021) Moderator: John V. Agapian, MD. Panelists: Sai P. Haranath, MBBS, MPH, FCCP; Claudio F. Lanata, MD, MPH; and Charles Feldman, MB BCh, DSc, PhD. For more tools to help in the fight against COVID-19, visit CHEST’s COVID-19 Resource Center at chestnet.org/COVID19.