The fourth-circuit affirmed the district court’s denial of a preliminary injunction against North Carolina’s Session Law 2024-31, which restricts the sale of electronic nicotine delivery systems (vapes) in the state. The court held that the Commercial Appellants possessed Article III standing because they faced a concrete and particularized financial injury—specifically, lost revenue and potential fines—that was traceable to the state’s enforcement of the law and redressable by judicial relief. The court rejected the argument that plaintiffs lack standing when their conduct also violates an unchallenged federal law, clarifying that Article III requires only a cognizable injury, not a legally protected right to engage in the regulated activity. On the merits, the court ruled that the Appellants were unlikely to succeed on their claim that the state law was preempted by the Federal Food, Drug, and Cosmetic Act (FDCA) and the Family Smoking Prevention and Tobacco Control Act (TCA). The court determined that the TCA’s “Preservation Clause” and “Savings Clause” expressly allow states to enact laws regulating the sale of tobacco products that are more stringent than federal requirements. Furthermore, the court found that the state law did not violate 21 U.S.C. § 337(a), which grants the FDA exclusive enforcement authority over the FDCA, because North Carolina was enforcing its own sales regulations rather than attempting to enforce federal pre-market approval requirements. The court also concluded that the state law did not stand as an obstacle to federal objectives, as Congress intended for states to retain traditional police powers over tobacco sales even while the FDA regulates product standards. The practical consequence is that the district court’s denial of the preliminary injunction stands, allowing North Carolina to proceed with enforcing its vape directory and sales restrictions. The Appellants may continue to litigate the preemption claim on the merits during the full trial, but they are not entitled to an immediate halt of the state law at this stage.