Alcohol use produces changes in the cardiovascular system affecting heart rate. These systematic differences in heart rate can, in turn, function as a biological signature (i.e., biomarker) of dysfunction among those with alcohol use disorder (AUD). In addition to assessing difficulties, understanding heart rate modulation may have important treatment implications. Dr. David Eddie talks about heart rate variability as a biomarker of AUD and his work developing behavioral skills that can target heart rate using biofeedback to improve AUD treatment outcomes. Dr. Eddie is an Assistant Professor at Harvard Medical School and a Research Scientist at both Massachusetts General Hospital’s Center for Addiction Medicine and Recovery Research Institute.