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Dual TKI targeting in Ph+ ALL; role of liver endothelial ferroportin in iron sensing and homeostasis; severe anemia in pregnant patients with beta-thalassemia minor
In this week's episode we'll learn about asciminib plus dasatinib in Philadelphia chromosome-positive acute leukemia. In a phase 1 study, combining two tyrosine kinase inhibitors with distinct mechanisms of action had encouraging activity in patients with de novo disease. After that: new research demonstrates that the iron exporter ferroportin contributes to the iron-sensing properties of liver endothelial cells. But is it the primary mediator of systemic iron homeostasis? Finally: anemia in pregnant patients with beta-thalassemia minor. In the third trimester, about one-third of patients have hemoglobin levels of 9 grams per deciliter or lower. This report may help to guide the appropriate diagnosis of anemia while limiting unnecessary testing and interventions.
Featured Articles:
- Asciminib plus dasatinib and prednisone for Philadelphia chromosome–positive acute leukemia
- The hepcidin-ferroportin axis modulates liver endothelial cell BMP expression to influence iron homeostasis in mice
- β-Thalassemia minor is associated with high rates of worsening anemia in pregnancy
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By American Society of Hematology
4.1
4949 ratings
In this week's episode we'll learn about asciminib plus dasatinib in Philadelphia chromosome-positive acute leukemia. In a phase 1 study, combining two tyrosine kinase inhibitors with distinct mechanisms of action had encouraging activity in patients with de novo disease. After that: new research demonstrates that the iron exporter ferroportin contributes to the iron-sensing properties of liver endothelial cells. But is it the primary mediator of systemic iron homeostasis? Finally: anemia in pregnant patients with beta-thalassemia minor. In the third trimester, about one-third of patients have hemoglobin levels of 9 grams per deciliter or lower. This report may help to guide the appropriate diagnosis of anemia while limiting unnecessary testing and interventions.
Featured Articles:
- Asciminib plus dasatinib and prednisone for Philadelphia chromosome–positive acute leukemia
- The hepcidin-ferroportin axis modulates liver endothelial cell BMP expression to influence iron homeostasis in mice
- β-Thalassemia minor is associated with high rates of worsening anemia in pregnancy
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