ECMO use expanded greatly during the COVID-19 pandemic. But despite this increased use, outcomes have been mixed. The use of this technique also requires substantial resources from health systems that are already stressed. In this episode, ARDS experts discuss the challenges of caring for the sickest patients with COVID-19. They also review the most recent lessons learned regarding patient selection and duration of treatment for COVID-19 ECMO. (Originally recorded January 13, 2022) Moderator: John Gaillard, MD, FCCP. Panelists: Cara Agerstrand, MD; Neil MacIntyre, MD, FCCP; Erik Osborn, MD; and Craig Rackley, MD, FCCP. For more tools to help in the fight against COVID-19, visit CHEST’s COVID-19 Resource Center at chestnet.org/COVID19.