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On April 1, 2006, 27-year-old Ohio State University medical student Brian Shaffer disappeared under mysterious circumstances. After a night out with friends at the Ugly Tuna Saloona in Columbus, Ohio, he was captured on surveillance footage entering the bar but was never seen leaving. Despite extensive investigations, including reviewing security footage and conducting searches, no trace of Brian has been found. The case remains unsolved, with theories ranging from accidental death to voluntary disappearance.

Marilyn "Niqui" McCown, a 28-year-old corrections officer from Richmond, Indiana, vanished on July 22, 2001, just three weeks before her wedding. After doing laundry at a local laundromat, she was never seen again. Her SUV was later found abandoned in Dayton, Ohio, with her laundry still inside. Despite investigations and various theories, including potential involvement of her fiancé, no conclusive evidence has emerged, and Niqui remains missing.

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