In this episode of BackTable ENT, Dr. Zara Patel, director of endoscopic skull base surgery and professor of otolaryngology at Stanford, joins Dr. Shah to discuss the physiology behind olfactory dysfunction and evidence-based cutting-edge therapies.

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SHOW NOTES

First, Dr. Shah and Dr. Patel outline different patterns of olfactory dysfunction and their etiologies. Damage to the olfactory system can result from inflammation, trauma, or neurodegeneration affecting olfactory bulb neurons. However, smell-based symptoms are common in migraine and seizure auras, so taking a thorough medical history is important in all patients. Also, they review “red-flag” medications contributing to smell loss.

Next, Dr. Shah asks Dr. Patel about the workup of patients with olfactory disturbance. Dr. Patel recommends rigid nasal endoscopy with and without decongestion for all patients with olfactory complaints. Unless another medical issue is suggested from the patient’s history, Dr. Patel does not routinely order labs for smell disturbance. The role of imaging is addressed, including use of MRIs for prognostication.

The doctors then cover evidence-based management of olfactory dysfunction. In cases where inflammation causes olfactory disturbance – such as post-viral etiologies – steroid therapy can help restore smell. To have effect, the drug must reach the olfactory cleft, so Dr. Patel prefers nasal rinses with budesonide over intranasal or oral steroids. Then, Dr. Shah shares her experience treating patients with olfactory training. Dr. Patel explains the neural basis of training and instructs clinicians on how to counsel patients for best outcomes.

Finally, Dr. Patel shares her expertise on hot topics in olfactory research, like the science behind platelet-rich plasma (PRP) for smell loss. She also reviews situations in which dietary supplements can improve symptoms. They end the episode with insights regarding equitable care of patients with smell-based symptoms.

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RESOURCES

Dr. Patel’s Stanford profile

https://profiles.stanford.edu/zara-patel

JAMA Patient Handout on Olfactory Training:

https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2782042

International Consensus Statement on Allergy and Rhinology:

Olfaction https://onlinelibrary.wiley.com/doi/10.1002/alr.22929