Every year, more than 6 million Americans suffer from chronic wounds such as diabetic foot ulcers and pressure injuries. Despite their prevalence, treatment hasn’t changed in decades — leaving patients vulnerable to infections, hospitalizations, and in the most severe cases, preventable amputations. The costs are staggering: an estimated $25 billion annually in direct care, not to mention the cascading burden on patients, families, and health systems. The lack of innovation in wound healing is not just a scientific problem, but a systemic one — rooted in misaligned incentives, slow regulatory pathways, and a lack of urgency in recognizing wounds as a major public health issue. Listen for a look inside the biotech race to regenerate skin and the End of Painful Skin Grafts, with Dr. Nikolai Sopko.