This week on BackTable Urology, Dr. Seth Lerner (Baylor College of Medicine) discusses the intricacies of lymph node dissection in bladder cancer management, including an overview of patterns of metastasis, genomic classifiers, and recent clinical trials.

The discussion highlights the evolution of bladder cancer treatment, from the use of cytotoxic chemotherapy to the current practice of neoadjuvant chemotherapy and radical cystectomy. Dr. Lerner and Dr. Bagrodia further explore diagnostic and treatment strategies, including the role of Decipher Prostate Genomic Classifier in tailoring patient treatment plans. The podcast delves into the necessity of a multidisciplinary approach to bladder cancer, the benefits of multimodal therapy, and the integration of circulating tumor DNA in management plans. Dr. Lerner then discusses clinical trials assessing the impact of extended lymph node dissection during cystectomies and emphasizes the importance of surgical quality and adherence to established protocols in bladder cancer treatment.

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SHOW NOTES

00:00 - Introduction

06:17 - The Role of Imaging in Bladder Cancer Staging

08:00 - Exploring the Potential of Genomic Classifiers

16:55 - Debating the Efficacy of Extended Lymph Node Dissection

27:47 - Update on Bladder Cancer Clinical Trials

48:54 - Final Thoughts and the Future of Bladder Cancer Treatment