Fertility Docs Uncensored is hosted by Dr. Carrie Bedient from the Fertility Center of Las Vegas, Dr. Susan Hudson from Texas Fertility Center, and Dr. Abby Eblen from Nashville Fertility Center. What is ovarian hyperstimulation syndrome (OHSS)? OHSS is a condition that can occur after ovarian stimulation, most often during IVF cycles, when the ovaries respond excessively to fertility medications. Who is at highest risk for OHSS? Patients at increased risk include women with a high egg count, younger patients, and patients with PCOS (polycystic ovary syndrome). Does pregnancy increase the risk of OHSS? Yes; a fresh embryo transfer can increase the risk because the pregnancy hormone (hCG) may worsen or prolong OHSS symptoms. How has the risk of OHSS decreased in modern IVF treatment? The use of GnRH agonist (Lupron) trigger shots has dramatically reduced the risk by quickly lowering estrogen levels and preventing severe symptoms. How is OHSS treated? Treatment focuses on symptom management; medications such as cabergoline (Dostinex) and letrozole may be used to lower estrogen levels and shorten symptom duration. When should patients call their doctor about OHSS symptoms? Patients should call immediately if they experience low urine output, an inability to drink fluids, severe abdominal pain, shortness of breath, or pain or swelling in the arms or legs. Why is it important to call your doctor if you are concerned? OHSS can be serious, and early evaluation and treatment are critical. Patients should always contact their doctor if they are worried about symptoms. This podcast was sponsored by U.S. Fertility.