Two Plus Two: The Swinger Podcast for Couples

Ep 48: STIs and the Swinger Lifestyle – Facts, Testing, and Trust


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This week, Zack, Josie, and Brad sit down with Callie — a Physician Assistant who works in the ER and has seen it all — to talk about one of the most important topics in the swinger lifestyle: sexual health.

Callie breaks down what everyone in the lifestyle should know about STI prevention, testing, and risk management. She explains how your risk isn’t just about your behavior, but also the behavior of your partners — and why trust, responsibility, and regular testing are essential for keeping everyone safe.

From women’s vaginal health and condom sensitivity to UTI prevention and the realities of unprotected oral sex, the conversation covers the practical side of pleasure. Callie also sheds light on HPV, how the vaccine has evolved, and how to approach testing — whether you test with your partner or alternate schedules.

Throughout the episode, the Crew explores how understanding your own risk tolerance, staying informed, and choosing responsible play partners can make all the difference. Because in the lifestyle, good sexual health isn’t just about protection — it’s about connection, communication, and confidence.


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(00:00:00) Callie is a PA and has 10 years of ER experience

(00:02:51) Fantasies - the gateway drug

(00:04:00) Condom use is a personal choice but there are risks

(00:06:49) This information is only an opinion and is not medical advice

(00:07:30) Anal tissue is more easily broken down so risk of STI is higher with anal sex

(00:08:29) Condoms and vaginal health

(00:10:00) More facts about vaginas

(00:11:11) Post menopausal vaginal decline, treatment and UTI prevention

(00:13:40) Condom use can be frustrating for men

(00:15:11) Oral sex and STI risks

(00:16:35) Deep dive on HPV

(00:19:39) The risks associated with oral vs vaginal sex are less severe

(00:20:26) Difference between STI ‘ and STD’s

(00:21:06) STI testing frequency and most common STI’s

(00:23:05) Throat and anal swabs by request only

(00:23:54) Most STI’s are asymptomatic so you have to test regularly

(00:25:11) STI testing funnies

(00:27:42) Testing frequency and alternating testing with your partner

(00:30:00) The partners you choose may influence testing frequency

(00:30:43) Sharing or asking for most recent test results

(00:34:50) You should be testing for these STI’s

(00:37:37) PREP

(00:39:30) Doxy PEP

(00:41:35) Prevention - condoms, regular testing, partners and substances

(00:43:00) Drugs, alcohol and high risk activities

(00:45:00) Gauging risk has a lot to do with the people and your intuition

(00:46:48) Trimix

(00:48:00) Stranger things…ER edition

(00:50:46) Preventative vaccines and screenings Callie recommends

(00:51:32) STI treatment app from CDC very helpful

(00:52:02) USPSTF - United States Preventative Services Task Force


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RESOURCES

STI Treatment App from CDC

USPSTF
Health care considerations for sex workers

Chlamydia and gonorrhea (Basics)

Genital herpes (Basics)

Sexually transmitted infections (Basics)
Sexually transmitted infection screening recommendations by sex assigned at birth and population

The five Ps: Partners, prevention of pregnancy, protection from STIs, practices, and past history of STIs
Why men who have sex with men have an increased risk of STIs

...more
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Two Plus Two: The Swinger Podcast for CouplesBy Zack, Josie, Brad, Brittany

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