Grab your hot beverage of choice and come out of the cold as we give you a warm welcome to the world of cold-dependent antibodies! No need to cry(o) as we unpack CAD vs CAS, get personal with PCH and gaze without alliteration at whatever the hell cryoglobulins are.  If you're desperate for a medical reason to move to the tropics, this is the episode for you.

00:58 - Deliberately inflammatory pop-culture discussions
02:45 - Clearing up nomenclature
6:12 - How cold is cold?
8:40 - Clinical case and problems with the FBC
13:27 - Testing for Cold Agglutinins & What are they binding?
16:14 - CAD, CAS and Causes
21:41 - Management - Stay toasty
28:07 - Cold Agg Summary
29:40 - Cryoglobulins
36:45 - Cryglobulinaemia Summary

NB We actually ran out of time to talk about PCH so apologies - keep an eye out in future episodes

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