even at very small some would argue barely even treating doses of testosterone patients had an increase rate of fractures with a NNH of 100—when you add this to the 1 risk of aki and 2 percent risk of arthymia the harms vs benefit conversation to use testosterone seems to be leaning heavy towards harms

https://www.nejm.org/doi/full/10.1056/NEJMoa2308836?query=recirc_curatedRelated_article