This episode of the ICHE Podcast discusses the Compendium and the newly released update to the Compendium, Strategies to Prevent Central Line-Associated Bloodstream Infections in Acute-Care Hospitals: 2022 Update. ICHE Editor-in-Chief David P. Calfee, MD, MS interviews Debbie Yokoe, MD, MPH, Lisa Maragakis, MD, MPH and Len Mermel, DO, ScM. First, they discuss the history of the Compendium, and review overall changes to the 2022 updates. Then, Dr. Len Mermel shares updates to the CLABSI document including changes to the essential and additional practices as well as implementation strategies. Strategies to Prevent CLABSI in Acute-Care Hospitals: 2022 Update is available in the May issue of ICHE and can be found here: www.cambridge.org/iche.