Bottom line

Omalizumab does seem to improve allergic reactions to peanuts but comes at a steep price tag. Likely only allergist will prescribe this drug but it is worth know about If you know or take care of anyone with severe peanut allergy.

After 16 weeks, 67% of patients who took omalizumab could tolerate a 600-mg peanut protein challenge (≈2 peanuts) versus 7% of controls.

Variability among patients was large: 44% of omalizumab patients could tolerate 25 peanuts whereas 14% of patients could not tolerate even 1/10 of a peanut.


https://www.nejm.org/doi/10.1056/NEJMoa2312382