In this episode of The ICHE Podcast, ICHE Editor-in-Chief, David Calfee, MD, MS, interviews members of the infection control unit, the biothreats program, and the infection disease division at Massachusetts General Hospital who were involved in the diagnosis and management of the first US recognized case of monkeypox of the current outbreak. They discuss the current global outbreak in relation to infection prevention and control in hospitals and other healthcare settings. Guests include Erica Shenoy, MD, PhD, Nesli Basgoz, MD, Kimon Zachary, MD, Eileen F. Searle, PhD, RN, CCRN, Meredith Fahy, MPH, RN, CIC.