This article presents an international retrospective cohort study examining the long-term clinical outcomes of patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). The research compares outcomes among different anatomical subtypes of aortic valves: tricuspid aortic valves (TAV) and bicuspid aortic valves (BAV), specifically types 0 (BAV-0) and 1 (BAV-1). Findings suggest that BAV-0 patients exhibit a better long-term prognosis after TAVR compared to both BAV-1 and TAV patients. Additionally, the study indicates that BAV patients who received self-expanding valves (SEV) had improved long-term outcomes over those receiving balloon-expandable valves (BEV). This multicenter study helps to understand the impact of valve morphology and device selection on post-TAVR survival over an extended period.