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Episode 402: 410. When You Shouldn't Double Down But Instead Hit for Another
This massive meta-analysis of 484 randomized, double-blind, placebo-controlled trials (104,176 participants) quantified the blood pressure–lowering effects of major antihypertensive drug classes and their combinations. It introduces a new intensity-based classification system and an online calculator to predict BP-lowering efficacy based on drug, dose, and baseline BP.
Study Design:
Key Findings
Monotherapy (Standard Dose):
Average SBP reduction: 8.7 mm Hg
By class:
Dose Doubling:
- Adds ~1.5 mm Hg SBP reduction (except β-blockers, which add only ~0.5 mm Hg)
Dual Therapy (Standard Dose of Each):
Average SBP reduction: 14.9 mm Hg
Triple Therapy:
SBP reduction: Up to 22.5 mm Hg (quadruple therapy even higher in one trial)
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By Questioning Medicine
4.9
7474 ratings
This massive meta-analysis of 484 randomized, double-blind, placebo-controlled trials (104,176 participants) quantified the blood pressure–lowering effects of major antihypertensive drug classes and their combinations. It introduces a new intensity-based classification system and an online calculator to predict BP-lowering efficacy based on drug, dose, and baseline BP.
Study Design:
Key Findings
Monotherapy (Standard Dose):
Average SBP reduction: 8.7 mm Hg
By class:
Dose Doubling:
- Adds ~1.5 mm Hg SBP reduction (except β-blockers, which add only ~0.5 mm Hg)
Dual Therapy (Standard Dose of Each):
Average SBP reduction: 14.9 mm Hg
Triple Therapy:
SBP reduction: Up to 22.5 mm Hg (quadruple therapy even higher in one trial)
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