Sign up to save your podcasts
Or
Share Episode 402: 410. When You Shouldn't Double Down But Instead Hit for Another
Share to email
Share to Facebook
Share to X
Share to email
Share to Facebook
Share to X
Or
Episode 402: 410. When You Shouldn't Double Down But Instead Hit for Another
This massive meta-analysis of 484 randomized, double-blind, placebo-controlled trials (104,176 participants) quantified the blood pressure–lowering effects of major antihypertensive drug classes and their combinations. It introduces a new intensity-based classification system and an online calculator to predict BP-lowering efficacy based on drug, dose, and baseline BP.
Study Design:
Key Findings
Monotherapy (Standard Dose):
Average SBP reduction: 8.7 mm Hg
By class:
Dose Doubling:
- Adds ~1.5 mm Hg SBP reduction (except β-blockers, which add only ~0.5 mm Hg)
Dual Therapy (Standard Dose of Each):
Average SBP reduction: 14.9 mm Hg
Triple Therapy:
SBP reduction: Up to 22.5 mm Hg (quadruple therapy even higher in one trial)
View all episodes
By Questioning Medicine
4.9
7474 ratings
This massive meta-analysis of 484 randomized, double-blind, placebo-controlled trials (104,176 participants) quantified the blood pressure–lowering effects of major antihypertensive drug classes and their combinations. It introduces a new intensity-based classification system and an online calculator to predict BP-lowering efficacy based on drug, dose, and baseline BP.
Study Design:
Key Findings
Monotherapy (Standard Dose):
Average SBP reduction: 8.7 mm Hg
By class:
Dose Doubling:
- Adds ~1.5 mm Hg SBP reduction (except β-blockers, which add only ~0.5 mm Hg)
Dual Therapy (Standard Dose of Each):
Average SBP reduction: 14.9 mm Hg
Triple Therapy:
SBP reduction: Up to 22.5 mm Hg (quadruple therapy even higher in one trial)
More shows like Questioning Medicine
View all
Global News Podcast
7,807 Listeners
Sawbones: A Marital Tour of Misguided Medicine
14,830 Listeners
JAMA Editors' Summary
134 Listeners
AFP: American Family Physician Podcast
696 Listeners
JAMA Clinical Reviews
502 Listeners
Frankly Speaking About Family Medicine
265 Listeners
White Coat Investor Podcast
2,453 Listeners
The Curbsiders Internal Medicine Podcast
3,366 Listeners
Up First from NPR
56,980 Listeners
Core IM | Internal Medicine Podcast
1,140 Listeners
The Matt Walsh Show
28,485 Listeners
Consider This from NPR
6,460 Listeners
The Curious Clinicians
371 Listeners
Huberman Lab
29,328 Listeners
The Checkup with Doctor Mike
1,330 Listeners