Bloody Minded

Episode 53 - PlateLOTS | Approaching Thrombocytosis


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There’s a problem with billionaires at the moment. Every day, you make a hundred billion platelets. For some in our society, even that colossal quantity isn’t nearly enough. They strive ever onward for even more. Unfettered platelet production all the time forever - after all the number can only go up. But mo’ platelets leads to mo’ problems. Go on a journey with Bashar, Nick and Cale to learn how some patients can become the Bezos of platelets and accumulate more than you can possibly need or want. Don’t let us stop you having a tacky wedding though. 

TIMESTAMPS

2:24 - Cutoffs (arbitrary as usual)  
4:24 - Platelet biology  
6:11 - TPO  
7:53 - Spurious thrombocytosis  
10:50 - Reactive thrombocytosis  
12:30 - Blood loss and thrombocytosis  
13:12 - TPO Kinetics  
16:00 - Iron deficiency and thrombocytosis  
19:10 - Hyposplenism  
20:03 - Drugs  
21:54 - MPNs  
23:53 - Molecular Testing  
25:27 - Clots AND Bleeds?!  
26:58 - A General Approach  
29:17 - Can we test TPO?  
30:29 - Case Study  
31:44 - Take Home Messages  

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