This episode explores how to extend the rapid but short-lived benefits of ketamine treatment for depression. While ketamine can significantly improve mood within 24 hours, these effects often fade within one to two weeks.

The focus is on a study investigating whether combining a single ketamine infusion with Automated Self-Association Training (ASAT), a computer-based training targeting self-worth, could prolong the antidepressant effect. The idea is that ketamine might create a window of enhanced neuroplasticity, making the brain more receptive to learning.

This original study can be found here.