How unlucky could one man be? His wife had taken her own life, and his college sweetheart had killed herself in much the same fashion fourteen years earlier. Investigators had to determine if this was a bizarre coincidence or an attempt to get away with murder... twice.

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In 1984, a couple set off for a camping trip but got lost and fell asleep at a scenic overlook in Virginia.

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After he got into the home, the assailant used an axe to kill the husband and critically injure his wife. Nothing was taken, so this wasn't a robbery. A DNA profile from skin cells collected hundreds of miles away would reveal the killer's identity and his motive for murder.

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A chemist suddenly starts to suffer from foot pain, partial numbness, and hair loss, and eventually dies. Could he have been poisoned?

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The woman in the back of the truck was flailing her arms, screaming. They thought she was doing something dangerous for the fun of it. But when they found a jacket near a pool of blood, they knew what they'd seen wasn't a joy ride; it was an abduction.

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Doctors don't know why the young scientist is gravely ill. When test finally reveal the cause, it's too late to save him. Police hope that lab analysis of his hair - showing when attempts were made on his life and what was used - will lead to the killer.

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When an 11-year old girl disappeared from a small town in a remote area of Alaska, investigators wondered if she'd been attacked by a bear or become lost int he dense woods. It turned out neither was true. Her body was discovered 10 days later; she'd been shot twice at close range, and sexually assaulted. A tip from an eyewitness led police to a suspect, and trace evidence found at the crime scene convinced a jury of his guilt.

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A nurse experienced flu-like symptoms. She visited the doctor for a check-up and learned she was HIV-positive. In the end, science was able to determine not only how she had been infected, but also by whom. The worst part: It wasn't an accident.

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A security guard disappeared from his post without a trace; his remains were found a year later in a remote camp site. More than a decade would pass before a phone call breathed life into the cold case, a paint smear on the bottom of the victim's boot helped scientists determine what happened during the last hour of his life.

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For years, a woman suffered from what appeared to be the unpleasant side effects of lithium, a drug prescribed to treat bipolar disorder. When she died, investigators had to determine if her death was due to natural causes, suicide or murder.

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