Frazis Capital Podcast

Frazis Capital Podcast

By Michael FrazisBusinessInvesting
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Frazis Capital Podcast episodes

  • Episode 46: Strategy in the Life Sciences
    Timestamps 
    ·      0:32 – Our fast-growing portfolio companies
    ·      2:21 - Frazis life sciences strategy update
    ·      5:18 – RNAi Biology
    ·      7:15 – Alnylam: RNAi clinical development pipeline and recent execution
    ·      8:16 – Timing and valuation in life sciences
    ·      9:26 – What do we think of CRISPER?
    ·      11:03 – Companies targeting sickle cell disease
    ·      11:56 – Companies targeting beta-thalassemia
    ·      12:53 – Platform technologies: Moderna
    ·      15:12 – Platform technologies: Ultragenyx
    ·      16:30 – Special focus: Alzheimer’s
    ·      18:50 –Alzheimer’s APOE4
    ·      23:50 – Could Alzheimer’s be caused by infection?
    ·      24:55 – Cortexyme: Alzheimer’s and the gingivalis hypothesis
    ·      27:00 – Cassava and Alzheimer's
    ·      28:30 – How are we different to Ark?
    ·      29:10 – Summary
    32 min
  • Episode 44: Dr Robert Stretch

    Dr. Robert Stretch is a specialist in Pulmonary, Critical Care & Sleep Medicine.

    After graduating from Yale School of Medicine in 2014, he completed subspecialty training at BIDMC, a Harvard teaching hospital in Boston, and UCLA Medical Center in Los Angeles.

    Timestamps

    0:05 – Introducing Robert Stretch

    0:25 – Robert’s journey studying medicine in the US

    3:40 – Findings when working on the MIMIC (Medical Information Mart for Intensive Care) database at MIT University

    9:31 – Robert’s move into sleep apnoea

    12:23 – What is sleep apnoea?

    16:47 – What are the main risk factors for developing sleep apnoea?

    17:26 – What is the current standard of care for sleep apnoea?

    18:26 – Working in US ICU’s remotely from Sydney

    23:11 – The need for remote ICU doctors

    26:00 – Robert’s experience treating Covid patients in ICU

    31:58 – Why are older people more vulnerable to Covid-19?

    33:19 – Assessment of the Australian government’s Covid-19 support and vaccine distribution

    40:30 – Outlook on Australian biotech companies

    46:52 – What is RNAi technology?

    52:40 – Pricing of vaccines and antibiotics globally

    59:04 – Link between Alzheimer’s and Gingivitis

    1 hr 5 min
  • Episode 43: Strategy update 22 April 2021

    0:15 – Introduction to Frazis Capital Partners.

    1:45 – Sell-off trends and SPAC’s.

    3:57 – Growth stocks outperforming tech indices.

    6:45 – Standpoint on growth stocks.

    9:18 – Software’s strong run.

    11:05 – Multiple contractions and what this means.

    13:30 – Teladoc Health.

    14:20 – View on Appharvest.

    16:45 – Batteries & developments in the lithium space.

    18:30 – Thoughts on DermTech.

    19:58 – Chinese regulatory risks.

    22:29 – What is a stock?

    24:15 – State of play for Xero.

    25:25 – What do we look for in a company?

    27:00 – Are we currently buying?

    28:21 – Thoughts on the Redbubble quarterly results.

    30:12 – Outlook on Airtasker.

    31:00 – Our current best stock play.

    32:24 – Perspective on Coinbase.

    34:40 – Key takeaways/Summary.

    38 min
  • Episode 42: Brian Hartzer, CEO of Westpac from 2014-2020, on leadership, culture and financial technology

    Brian Hartzer joins us to talk about his new book 'The Leadership Star', available from Amazon. 

    Brian was CEO of Westpac from 2014-2020. For those who don't know Westpac is Australia's second largest bank with over $800 billion of assets. 

    Brian discusses his 'Leadership Star' framework and pivotal moments in Australia's banking history. Brian also shares his views on cryptocurrency, neobanks, alternative lenders, the Buy-Now-Pay-Later movement, and the future of financial technology more broadly.  


    Timestamps

    00:05 – Introducing Brian

    03:15 – Brian's new book: ‘The Leadership Star: A Practical Guide to Building Engagement’
    06:00 – Shifting from management consulting to running ANZ’s credit card business
    08:25 – Brian’s perspective on the evolution of credit cards in Australia
    10:25 – The five c’s of leadership: care, context, clarity, clearing the way and celebrate
    11:05 – Why the phrase ‘I’m just a teller’ is a sign of bad management
    13:00 – Why cleaners are the most important workers at Disney
    14:10 – ‘Clearing the way’ - what does this mean?
    15:50 – How corporate and leadership culture has changed over Brian’s career
    18:46 – How Brian navigated the “biggest bank failure in history”
    20:25 – What led to the downfall of RBS
    23:37 – Brian’s perspective on the evolution of US corporate culture
    24:50 – The state of banking technology in the UK
    28:58 – Why more competitors doesn’t necessarily equal better consumer outcomes
    29:17 – How the banking landscape helped Australia navigate the GFC
    31:35 – Behind the scenes of the Australian banking crisis in 1991/1992
    32:58 – Why hybrid bank branches are the way of the future
    36:15 – Multi-brand strategies and Westpac
    39:30 – Brian’s thoughts on the buy-now-pay-later sector
    42:28 – Will the buy-now-pay-later sector will displace credit cards?
    44:58 – Views on Bitcoin and why Brian pushed through Westpac's investment in Coinbase
    49:20 – The “one and only legitimate” use case for bitcoin
    50:50 – The future of neobanks and alternative lenders
    54:15 – Predictions on the future of banking technology
    55:45 – Brian’s pivot to working as an angel investor
    57:50 – The one key takeaway from Brian’s new book

    1 hr
  • Episode 41: Where to next? SPACs, rising interest rates and tech stocks

    Michael Frazis gives an update on SPACs, rising interest rates, tech valuations and what might happen next.

    Timestamps

     1:35 - Quick review of 2021 
     2:30 - Thoughts on Cathie Wood and ARK
     3:59 - Expansions and contractions in software multiples
     7:40 - Snowflake 
     8:47 - SPACs: why we like them and why they're dangerous (hint: the same reason)
    12:02 - Why we hope SPACs encourage leading tech firms to list sooner
    14:21 - Dodgy forecasts
    16:51 - Why we rule out most SPACs in the fund
    18:00 - Navigating rising interest rates 
    22:33 - The recent sell-off
    24:32 - How we look at market rotations
    26:46 - Coupang IPO

    29 min
  • Episode 40: Gamestop

    January 2021 - one of the more amusing weeks of finance. 

    0:57 - The short squeeze

    2:31 - The reality of Robinhood's 'free' trades
    5:08 - The hidden consequences of Hedge Fund strategy
    6:51 - How useful is management access?
    9:56 - The gamma squeeze
    12:15 - How this forced people to rethink how they discuss finance?
    13:39 - Is the squeeze squoze?
    14:37 - Timing and recovery
    15:40 - Our strategy
    17:24 - An important dynamic of short interest
    19:43 - The true signal of growth
    20:32 - How fund managers missed a multidecade trend?
    23:00 - A changing guard in allocation decisions

    25 min
  • Episode 39: January 2021 Strategy Update

    1.40 - Quick review of 2020 

    2.35 - How to survive huge market swings like March 2020 and 2008-2009 

    3.45 - Discussion on support mechanisms in place in equity markets (central banks, fiscal stimulus, actions by management teams, etc) 

    5.45 - Current investment strategy is to stay invested & make sure we are constantly holding winners 

    7.35 - Sound fundamental reasons why companies with intense customer love, explosive growth, and market leadership perform so well 

    8.15 - Our companies are investing heavily. When revenue comes in they open new offices, hire marketing staff and etc which promises a greater return on investment. Many categorise these investments as costs, which gives the opposite (incorrect) answer 

    10.17 - Investment in tech and the "companies of the future" requires long term investment with value creation over 5 - 10 years 

    11.50 - Question: Have you invested in Nio? Nio capitalises on the necessity of an electric China. There is demand in the Chinese economy with issues like pollution for electric vehicles and the vast majority of the population will be buying locally made vehicles. Nio is a 100%+ revenue growth company and has proven user base in China 

    13.25 - Question: When do we trim? Focus of maintaining diversified portfolio of ultra-high growth companies 

    14.25 - Long term goals of the fund 

    16.17 - Question: Is there a limit to when printing to support the economy triggers inflation? Austerity weakened the private sector as seen in the UK and saw mass unemployment 17.14 - Comparison with the Australian experience 

    18.08 - The Greek experience with austerity, and how growth can be the solution to an economic crisis 20.20 - Worries around debt overhang have been consistently proven wrong for countries like Australia, Japan, UK and USA anyway 

    20.50 - Question: How are you investing in the life sciences? 22.23 - Discussion on liquid biopsy and Dermtech's sticker approach to melanoma 24.00 - Question: What do we think about SPACs? 

    26.20 - Question: what didn't work in 2020? A few biotechs underperformed, like Avita 

    27.40 - Discussion on Moderna now that vaccine is approved 

    30.33 - Market outlook: Market is changing with stimulus, vaccines and substantial changes in leadership with low interest rates 

    30.45 - At the highs of January 2021 we aim to stay consistent & ensure our portfolio companies are adding users and revenues everyday at the highest possible rates, just as we did in the lows 

    33.10 - Question: What do we think of high quality but richly priced companies like Crowdstrike? 

    33.23 - 2021 focus on life sciences - the space is independent over the growth space & captures novel explosive growth 

    34.10 - Always searching for companies that grow 100% year on year, trading on five-time sales  

    34.25 - Why we never bought Spotify 

    35.10 - Question: Are we in a tech bubble? 

    44.30 - Conclusion: we remain focused on our diversified portfolio of ultra-high growth companies intense customer love, long term



    44 min

About Frazis Capital Podcast

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Michael Frazis and Ellianna discuss the life sciences, technology, and their latest investment ideas.

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