From the Spectrum: Finding Superpowers with Autism

For today's episode, we discuss Autism with Dr. Yehezkel Ben-Ari. Dr. Ben-Ari is a pioneer in the field of human development with over five decades of academic and private research. He has over 520 publications with a strong passion for early detection and treatment of brain disorders. His work includes studying Human Development, Autism, Epilepsy, Parkinson's, and Brain Tumors. He is a leader in how science understands the roles GABA and Chloride during early development and the NCCK1 importer and KCC2 exporter during the Excitation/Inhibition shift.

In 1986, he led INSERM Neurobiology and Pathophysiology of Development before shifting to Start-Up private investigation in 2008. He is the founder of Neurocholre, B & A Biomedical, B & A Oncomedical, INMED, and IBEN. Recently, Dr. Ben-Ari has made wonderful contributions towards Autism identification in the Placenta using the work of "Neuroarchaeology" and Machine Learning. Dr. Ben-Ari is the recipient of many awards including Grand Prix de l'INSERM, Grand Prix European Society of Epilepsy, and Grand Prix Gagne Van Heck Belgian National Scientific Research (FNRS), to name a few. His book, The First 1000 Days, will soon have an English version. Treating Autism with Bumetanide is available now.

Dr. Yehezkel Ben-Ari https://www.inmed.fr/en/evenement/en-yehezkel-ben-ari

Neurochlore https://www.neurochlore.fr/en/

Machine Learning https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994821/

Excitatory Actions of GABA https://www.nature.com/articles/nrn920

GABA https://journals.physiology.org/doi/full/10.1152/physrev.00017.2006

Neuro-Archaeology https://pubmed.ncbi.nlm.nih.gov/18951639/e

Books: https://www.amazon.com/s?k=yehezkel+ben-ari&crid=1LZK6JWEBG4NC&sprefix=yehezkel+ben-ari%2Caps%2C196&ref=nb_sb_noss

0:00 Dr. Yehezkel Ben-Ari

3:08 Understanding Autism: Origins and Early Detection

8:08 The Roles of Machine Learning Data Analysis in Identification

14:56 The Impact of Environment and Autism

23:18 Treatment Approaches and Efficacy, Bumetanide, and NKKC1 Inhibitors

31:04 Challenges in Autism Research, including the Genetic Debate, Medical Paradigms, and Decision-Makers

38:00 Future Direction and Innovative Research, Autism in the Placenta and the Environment during Pregnancy

53:56 Wrap Up / Reviews and Ratings, Contact Info

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: [email protected]

For today, just a brief introduction to research beginning at UT-Austin, University of Texas at Austin, led by Dr. Francisco Gonzalez-Lima. The study is called: Effects of Transcranial Infrared Light Stimulation on Symptoms of Autism Spectrum Disorder. In the link below, it is Study #2.

Dr. Francisco Gonzalez-Lima https://dellmed.utexas.edu/directory/francisco-gonzalez-lima

Research Link (Study #2) https://labs.la.utexas.edu/gonzalez-lima/participate-in-our-research/

Research Team https://labs.la.utexas.edu/gonzalez-lima/team/

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: [email protected]

In this episode, we discuss eye-tracking as an early biomarker for Autism. Eye-tracking, on infants, improve assessment outcomes at young ages, as young as 14-months-old. Adding biomarkers to the assessment process is valuable, and Autism research is beginning to offer more biomarkers. We've covered biomarkers in cellular respiration, serotonin, two studies on 6-week-olds- 1) predicted profound Autism with brain cortical organoids and 2) salience network connectivity. Today, we review four scientific papers on eye-tracking being added to the assessment process.

A valuable consideration is the roles our eyes have on brain development, which we cover as well.

Pierce et al 2019 https://pubmed.ncbi.nlm.nih.gov/31034004/

Wen et al 2022 https://www.nature.com/articles/s41598-022-08102-6

Keehn et al 2024 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818669

Early Autism Evaluation (EAE) https://medicine.iu.edu/expertise/indiana-health/access-to-care/autism/care

Rudling et al 2024 https://journals.sagepub.com/doi/full/10.1177/13623613231203037

The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://www.youtube.com/watch?v=DAtmC-s1_e0

0:00 Intro; 2 studies on 6-week-olds; Eye Development and Brain Development, Opsins

5:23 OCT (Optical Coherence Tomography) scans and Brain predictors, Melanopsin

7:06 Melanin and Melanopsin through the body and biochemistry

8:39 Fruit Tree Example from Dr. Kruse

9:29 Eye-tracking and Autism as a Biomarker; Neuroplasticity- Human's capacity to think; Autism is NEW in human evolution

14:05 Social Attention; Oxytocin- magnocellular and parvocellular; Objects over People; Gaze Following

17:21 Gaze Attention

18:02 Joint Attention

19:12 Studies on Infants; Pierce et al, 2019

25:00 Wen et al, 2022

27:03 Keehn et al, 2024 and Early Autism Evaluations (EAE)

29:25 Rudling et al, 2024

32:15 Wrap-Up/Final Thoughts

34:55 Reviews/Ratings, Contact Info

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: [email protected]

For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.

He currently sees patients as a Neurologists and Director of Research at Rossingnol Medical Center and at Neurodevelopmental Precision Medicine. In 2022, Dr. Frye co-founded the Autism Discovery and Treatment Foundation where they are dedicated to discover biomarkers, metabolic endophenotypes, and treatments for neurodevelopemental disorders.

Dr. Frye shares many figures during the conversation so the listener can follow along.

Dr, Richard Frye https://drfryemdphd.com

CV https://wparticles.seek2understand.org/wp-content/uploads/2023/02/DrFryeCVJan2023.pdf

Rossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenter

Neurobiology of Disease 2024 paper https://www.sciencedirect.com/science/article/pii/S0969996124001190?via%3Dihub

Autism and GI, and exploring how changes in Light have major implications (Apple) https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000664349495

0:00 Dr. Richard Frye

6:13 Intro into mitochondria & energy production, various disease & dysfunction

11:16 Mitochondrial DNA, sensitivity, and the roles with epigenetics

16:16 Biomarkers of mitochondrial dysfunction, delicate delivery (space and time) into the electron transport chain

20:58 Cytochrome C Oxidase (complex IV); Carnitine, Fat, and Creatine

26:57 Molecules connected to aging & cellular respiration, environemental signals implicating mitochondria

30:26 Terrible Trio: oxidative stress, mitochondria dysfunction, immune/inflammation, DAMPS & inflammation

34:29 Environmental risks for the Embryo, overreactivity of mitochondria (200%) and physiological insults and regression

42:50 Tryptophan (aromatic amino acid), NAD, and Gastrointestinal biosynthesis

45:52 Light as an environmental change factoring into the Autistic Phenotype, Infant Tree and Adult Tree examples; Vitamin D (skin & brain are connected through Neuroectoderm)

54:54 Future Research

59:58 Wrap up, Reviews/Ratings

X: https://twitter.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: [email protected]

In this episode, we discuss the mitochondria. You know mitochondria as the "powerhouse" of the cell, but this biological process is biophysics meeting biochemistry. We discuss glycolysis, the TCA cycle (or Citric Acid cycle or Krebs cycle), and Oxidative Phosphorylation. This discussion goes deep inside the atomic molecular level with electrons and protons. Hang in there with the discussion and topic of Autism and understanding of the generational link to a loss of electrons.

Jack Kruse https://www.patreon.com/DrJackKruse/posts

Glycolysis https://www.ncbi.nlm.nih.gov/books/NBK470170/#:~:text=Glycolysis%20is%20a%20central%20metabolic,use%20in%20other%20metabolic%20pathways.

Citric Acid cycle https://en.wikipedia.org/wiki/Citric_acid_cycle

Oxidative Phosphorylation https://en.wikipedia.org/wiki/Oxidative_phosphorylation

0:00 Intro; Light, water, magnetism; The "powerhouse" and understanding of healthy living organisms and different cell types; Photosynthesis and Cell Respiration

4:11 Prokaryotes, Eukaryotes, and Cytochrome C Oxidase (CCO)

6:53 Mitochondria and Cellular Respiration 1) Glycolysis, 2) Citric Acid cycle, and 3) Oxidative Phosphorylation (OXPHOS)

8:25 Glycolysis

10:03 Citric Acid cycle

12:02 OXPHOS

13:51 Cytochrome I

15:07 Cytochrome II

16:08 Cytochrome III

17:10 Cytochrome IV and creating water

19:56 Not all water is equal/same; Aging; Light and Melanin and Rates of Autism

29:20 Cytochrome V and ATPase; Chromophores

33:56 Evolution and losing electrons; Autism and modern health complications

37:50 Environmental signals due DNA sequencing; Autism research and Genetic studies

40:23 Reviews/Ratings and contact info

X: https://twitter.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: [email protected]

In this episode, we challenge the modern trend of Autism and ADHD comorbid diagnosis. We will use children from Kanner and Asperger to show these so-called ADHD symptoms are simply parts of the Autistic Phenotype. However, society finds it easier to lump these two conditions together, and we question why. We review both, the inattentive criteria and the hyperactivity and impulsivity of ADHD and explain when the Autistic phenotype exhibit these conditions.

The criteria for ADHD are downstream behaviors seen across multiple reasons and act as a collect-all. I did not say ADHD does not exist, but I do say Autism and ADHD existing simultaneously seems unlikely if you really understand the phenotypes. Might it just be easier for society to lump these together instead of challenging the differences?

B.3 and Inattention are complete opposites. Hyperactivity and Impulsivity can show up when anyone is in the wrong or horrible environment.

Autism and ADHD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918663/

Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf

Hans Asperger https://psycnet.apa.org/record/1992-97284-002

0:00 Intro; Brief Note on how environmental signals such as electromagnetic fields (EMF, i.e., Light) informs the genes on how to respond, and how disease manifests

2:51 Autism and ADHD; Neurodiversity; and some problems in society

7:58 Core of Autism- B.3, and Donald Triplett example; B.2 and Social Communication

13:27 Autistic Phenotypes

19:01 ADHD Phenotypes

21:41 Specifiers and Lumping Contrasting Phenotypes

33:18 Medication and ODD (Oppositional Defiant Disorder) Rant

35:42 Autism conundrum with ADHD

38:45 Reviews/Ratings and Contact Info

Hopp: https://www.hopp.bio/fromthespectrum

X: https://twitter.com/rps47586

email: [email protected]

My guest today is Jonathan Mitchell. Jonathan is a senior citizen Autistic, Author of numerous novels and blogs, and stands up for the purpose of Autism. His blog, Autism Gadfly, provides perspectives of Autism otherwise not considered by the lay-public or researchers in Autism. Jonathan's views have been mentioned in Newsweek, NPR, Autism Daily Newscast, and HuffPost.

Jonathan was born in 1955 in Los Angeles. We discuss his experience at an early age including psychoanalytic therapy, psychological assessment, and troubles through education. Eventually, Jonathan and his family learned about Autism while on a trip to the East. Jonathan faced many challenges through his education in different schools beginning in kindergarten. However, Jonathan graduated from UCLA with a bachelors of arts in psychology.

We also discuss challenges in professional and personal life as an adult where he faced various barriers. In the early 2000s, when the internet allowed for different communication platforms, Jonathan began to call out things wrong in Autism. In addition, he carries a loud voice for a cure/treatment for Autism. Recently, you can find him on X as he continues to be a voice for the Autistic community.

The Mu Rhythm Bluff https://www.amazon.com/Mu-Rhythm-Bluff-Jonathan-Mitchell-ebook/dp/B00BQN84GM/ref=sr_1_1?crid=2UHATAWKAT5YA&dib=eyJ2IjoiMSJ9.eocnp6hSIjLZqAuzxnIcPw.vv03H-Vx-BeqtHx4_dYo4W6QomZdOkuZ4JEBPgbA-IQ&dib_tag=se&keywords=the+mu+rhythm+bluff&qid=1724157644&sprefix=the+mu+rhy%2Caps%2C104&sr=8-1

X: https://twitter.com/autismgadfly

Jonathan Mitchell website http://www.jonathans-stories.com

Wikipedia https://en.wikipedia.org/wiki/Jonathan_Mitchell_(writer)

Hans Asperger called the children "little professors"- This is Autism.

In this episode, we explore criteria B.3, which is the core of Autism. Donald Triplett's father's first sentence to Leo Kanner- He seems self-satisfied.

Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf

Hans Asperger https://psycnet.apa.org/record/1992-97284-002

Erwin Schrödinger https://en.wikipedia.org/wiki/Erwin_Schrödinger

0:00 Intro, Erwin Schrödinger and Leo Kanner; Light gives Life to Cells

2:29 B.3

5:15 Hans Asperger, Autist

7:19 Leo Kanner

8:31 Paths to Superpowers; Autism and Education; Medicine and Charles Sidney Burwell

13:50 Personal Experiences; Vietnam War; B.2 complications with B.3

15:22 Baseball Game and Probability

16:52 Adult Examples

17:55 1950s and Novel- example of Abnormal B.3; Thinking in Pictures and Supplementing Relationships

21:29 Disruptions from unplanned or outside interference; Medication Approach and Warning

23:36 Unusual Objects; ADHD prep; Finding interests in Life

26:31 Check-Out lanes and Autism; Self-Satisified- This is Autism

28:53 Circumscribed

31:36 Perseverative; The Nervous System

35:44 Bible; Inner-focus using B.3 as a Superpower and directing focus

39:16 Dogs and Snakes

39:50 Autistic Phenotype and B.3 at the Center

40:30 Reviews/Ratings and Contact Info

X: https://twitter.com/rps47586

Hopp: https://hopp.bio/fromthespectrum

email: [email protected]

In this episode, we explore typical topics with Autism research and try to understand the purpose. Autism research is confounding, and maybe, lacks direction. We offer a research suggestion based on the most plausible cause of Autism- the new modern day environmental factor- Artificial Light. Remember, Autism just shows up, so it makes sense to send the mother and father back to an environment pre-Autism.

Quantum Biology https://www.patreon.com/DrJackKruse/posts

Photobiological Implications of Folate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862485/

B9 (folate) and B12 (cobalamin) are Photoreceptors, too.

0:00 Autism Research Direction and missing the beginning; Is it Click-Bait?; Confounding

3:30 Changes in Light and the Full Spectrum; the number of Genes involved with Autism Research

5:07 Genetic Variants, Copy Number, Duplications, Deletions

7:04 Gene-Envrionment Interaction; MTHFR; Methylation, Myelin

13:03 Brain Connectivity and Neurobiology

13:55 Socio-Environmental/Socioeconomic; Robert Sapolsky

14:25 Early Diagnosis and Bio-markers

14:47 Comorbid Conditions

16:05 Personalized Interventions

16:27 Medications and the PROFIT MILL

18:36 Today's Purpose; Parental Melanin, Artificial Light, and nnEMF

19:30 Research Idea with 3 Groups and Returning the Environment before Autism magically shows up

25:17 Shift-Work Warning

26:20 Back to Autism; Amish

29:07 Reviews/Ratings, Contact Info

X: https://twitter.com/rps47586

Hopp: hopp.bio/fromthespectrum

email: [email protected]

In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment.

Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis.

Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496

Su study: https://www.nature.com/articles/s41564-024-01739-1

Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/

Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9

Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/posts

(0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions

(3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems

(6:22) POMC; HPA; Stress example

(8:19) Common Autism problems in the GI

(9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation

(14:09) Melanin/POMC; Clock-Timing; Omentum

(16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut

(19:04) Vitamin D Receptors and more Clock-Timing

(22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids

(24:33) Avoiding UV Light implications

(26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data

(30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles

(32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD

(38:27) Reviews/Ratings and Contact Info

X: https://x.com/rps47586

Email: [email protected]