Frostbite has long been one of the most feared cold-weather injuries for mountaineers, backcountry skiers, and winter adventurers—often leading to permanent tissue loss or even amputation. In this episode, we explore how frostbite happens, how to prevent it in the outdoors, and what to do when it strikes far from help. We also highlight a breakthrough in treatment: the FDA’s recent approval of iloprost, the first medication specifically designed to save tissue and improve outcomes in severe frostbite. From backcountry prevention tips to cutting-edge hospital care, this conversation brings together wilderness safety and modern science to help outdoor athletes and medical providers better understand and manage frostbite.