This week on 'Journals', Dr. Shanmugam has invited Dr Joann B Sweasy and Dr. Westley Reeves to discuss a paper with an interesting journey, "A Human MSH6 Germline Variant Associated with Systemic Lupus Erythematosus Induces Lupus-Like Disease in Mice". In this paper, we discover that the science is always telling us something, regardless of where we believe we're headed and where we ultimately end up. This lupus study has such a story. Join us as our guests explain the study's objective, the interesting results, what they did to achieve them and their overall conclusion.