Our guest this week is Dr. Tony Merriman, whose latest work: "Association of Gout Polygenic Risk Score With Age at Disease Onset and Tophaceous Disease in European and Polynesian Men With Gout", attempted to determine whether a gout polygenic risk score (PRS) is associated with age at gout onset and tophaceous disease in European, East Polynesian, and West Polynesian men and women with gout. However, what this study found regarding the predictability of these associations, specifically how it affects men and women differently, may have been something no one could have predicted.