In this Giants of Cardiothoracic Surgery interview, Joel Dunning speaks with Oscar Howard “Bud” Frazier about his career. Dr Frazier trained with Michael DeBakey and Denton Cooley while they were developing the first mechanical heart. He continued and advanced this work throughout his career while also performing over 1,200 heart transplants and over 500 left ventricular assist devices (LVAD). Dr Frazier also performed the first HeartMate implantation and the first Jarvik implantation. He has been an instrumental part of mechanical heart development and continues to take a close interest in this rapidly advancing field.