People are living longer lives than in the past. With the aging of the baby boomers, the percentage of people older than sixty- five will comprise more than 22 % of the population by 2030. Unfortunately, age-associated chronic diseases and conditions are increasing just as fast. It is not likely that there will be a single scientific breakthrough that will extend our life expectancies. Rather Dr. Giuliano believes that life extension will be through a series of small steps including small hermetic challenges to positively tweak our metabolic functioning in a positive direction One such tweak is caloric restriction, intermittent fasting. Others include small exposures to other stressful situation such as cold and exercise