After the white smoke emerged above the Sistine Chapel on Thursday afternoon, Chicago native Robert Prevost was introduced as the new pope. Prevost is the first pope from North America. National Catholic Reporter executive editor James Grimaldi joins us. Then, President Trump has come to an agreement with the United Kingdom, marking the first trade deal since Trump imposed tariffs on a host of countries. We outline the details of the deal with The Financial Times' Rana Foroohar. Plus, officials from the United States and China are meeting in Switzerland this weekend for the first talks since the Trump administration jacked up tariffs on Chinese imports to 145% and China responded with 125% tariffs on U.S. goods last month. China expert Elizabeth Economy talks about the trade war. And, a federal judge is warning the Trump administration against its plans to deport migrants in the U.S. to Libya. Abdulkader Assad, senior political editor at the Libya Observer, tells us more.

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We go to St. Peter's Square as Roman Catholic cardinals gather in the Sistine Chapel to select the next pope. David Gibson of Fordham University is there, along with NPR's Daniel Burke and Claire Giangravè of Religion News Service. And, India launched what it called retaliatory missiles at Pakistan early Wednesday morning. Pakistan is considering it an act of war. Milan Vaishnav of the Carnegie Endowment for International Peace explains what's at stake for the two countries. Then, President Trump reportedly plans to shut down Energy Star, a program that has helped consumers find energy-efficient appliances since 1992. Grist's Tik Root tells us what the move could mean.

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Aviation safety consultant Jeff Guzzetti talks about concerns for flight safety nationwide following an incident last week at Newark Airport, where air traffic controllers briefly lost all contact with airplanes trying to take off and land there. Then, a new immunotherapy drug could help some cancer patients avoid surgery. Oncologist Dr. Andrea Cercek joins us to discuss. And, Black Dandyism and superfine tailoring took the stage at Monday night's annual Met Gala. Jonathan Square, an adviser to the Metropolitan Museum of Art, talks about what this celebration of traditional Black fashion means in our cultural and political moment.

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As consumers brace for fewer options and higher prices on store shelves, Northwest Seaport Alliance co-chair and Port of Tacoma president John McCarthy explains the ripple effect that an expected decline in shipping will have on the U.S. economy. And, Israel has a new plan to "capture Gaza" and take control of the distribution of humanitarian food and aid supplies. CNN's Jerusalem correspondent Jeremy Diamond shares more. Then, a U.S. official tells NPR Ukraine is getting more military support as the Trump administration sends a Patriot air-defense system to the country from Israel. Ukraine-based foreign policy analyst Hanna Shelest tells us what the move means.

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Author Isabel Allende talks about her new book, "My Name is Emilia Del Valle," a historical romance set in the late 1800s about a young female journalist who goes to Chile to cover a brewing civil war. Then, author Zara Chowdhary tells her deeply personal story of growing up in India during a period of anti-Muslim violence in "The Lucky Ones." The book has just been announced as a finalist in the PEN/John Kenneth Galbraith Award for Non-Fiction. And, when his wife, the fashion designer Anna Huling, was diagnosed with Alzheimer's disease in her forties, author Stephen Sicliano began documenting the beautiful settings and local trips the couple and their son took around their Southern California home. Stephen eventually turned it into a book called "Three Surfin' Safari Summers."

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As President Trump's tariffs take effect, many American consumers will have to wean themselves off cheap goods made in China. Former President Joe Biden's economic adviser Jared Bernstein joins us for more. And, as climate change makes heavy rainfall in London more frequent, Here & Now's Chris Bentley reports on the city's "super sewer" system, designed to keep sewage out of the Thames River. Then, Here & Now's James Mastromarino discusses three surprising video game hits: an unexpected remaster of "The Elder Scrolls IV: Oblivion," the French RPG "Clair Obscur: Expedition 33," and indie puzzle game "Blue Prince."

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Wednesday marks Trump's 100th day in office. NPR's Scott Horsley looks at the economy after 100 days of the second Trump administration. Then, government programs that serve kids are among the many being slashed by the Trump administration. ProPublica's Eli Hager tells us how those cuts will affect the nation's most vulnerable children. And, we check in with two people who voted for Trump. We hear from Jordan Willey and Tracey Danka.

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Several American citizen children have been sent out of the U.S. in recent days, alongside a parent who was deported, including a four-year-old with late-stage cancer. Doris Meissner of the Migration Policy Institute shares more about what's happening. And, Trump border czar Tom Homan visited Rochester, New York Tuesday, after President Trump signed an executive order targeting federal funding for "sanctuary cities". Reporter Gino Fanelli explains more. Then, it has been 80 years since the liberation of Hitler's concentration camps. Elly Gotz, a 97-year-old survivor of Germany's Dachau, and Dan Stone of the Holocaust Research Institute join us.

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Secretary of State Marco Rubio released a plan to reorganize the State Department that would eliminate human-rights-focused bureaus and reduce U.S. staff. Jessica Stern, former U.S. special envoy for the human rights of LGBTQ+ persons, joins us. Then, concern is growing that extremism and white supremacism in the military may now be going unchecked. The Trump administration did away with a program to track and combat the issue. Heidi Beirich, co-founder of the Global Project Against Hate and Extremism, tells us more. And, author Chris Whipple talks about the role that President Trump's chief of staff Susie Wiles has played in Trump's action-packed second-term honeymoon period.

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Chicago is set to break ground on a pipeline that will bring water from the Great Lakes to some suburbs whose groundwater is running dry. Joliet, Illinois, is one of those suburbs. Here & Now's Chris Bentley reports on the question of who is allowed to use Lake Michigan's water. And, as cities across the West brace for a drier future, they're investing in advanced water purification technology. Here & Now's Peter O'Dowd reports on scientists who are turning wastewater into drinking water. Then, desalination — pulling fresh, drinkable water from saltwater— can offer some relief in areas facing water shortages. Robert Bergstrom, CEO of OceanWell, explains how the company's desalination pods work. And mechanical engineer Amos Winter details how his team uses an electrodialysis system to purify groundwater.

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