Causes or Cures

How a Low-Cost Antibiotic Could Prevent Sepsis in Childbirth & Save Millions of Women's Lives, with Dr. Michael Santos


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In this episode of Causes or Cures, Dr. Eeks chats wit Dr. Michael Santos about the A-PLUS trial, published in The New England Journal of Medicine, which looked at the effects of a cheap, widely available antibiotic, Azithromycin, in preventing sepsis and death in women during childbirth in low- to middle-income countries. Dr. Santos will explain the prevalence and life-threatening nature of sepsis in women during childbirth, particularly in low-resource settings. He will discuss what they knew about Azithromycin and maternal sepsis prior to the study, how they recruited for this study and conducted it, the results they found, and the wider public health implications.

Dr. Santos is Vice President of Science at the Foundations for the National Intitutes of Health (FNIH)  and was in charge of the work FNIH did on the A-PLUS trial. He was previously Deputy Director of the Global Health program of the Bill & Melinda Gates Foundation.


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