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Can a Daily Supplement Really Reverse Biological Age? A 12-Month Study, Explained

What actually happens when real people take a daily “healthy aging” supplement for an entire year?

In this episode of Causes or Cures, Dr. Eeks sits down with Dr. Varun Dwaraka of TruDiagnostic to unpack the results of a 12-month clinical study of the Cel System, a supplement regimen tested in adults aged 54 to 84.

We dive into:

• Why this supplement was developed in the first place
• How the study was designed, including regular checkpoints
• What biological or “epigenetic” age tests really measure (in plain language)
• Why different biological clocks sometimes disagree
• What it means to analyze the apparent age of specific body systems
• What results the team saw after a year
• What those findings do—and don’t—mean for slowing aging
• Big caveats and what smarter, next-gen studies could look like

If you’re curious about “reversing” biological age or just want the hype filtered before you spend money on a supplement, this one’s for you.

🧪 Read the peer-reviewed study published in Aging: https://www.aging-us.com/article/206221/text

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Modern medicine rests on a centuries‑old decision to split mind from body. That fault line still runs through every clinic and classroom, raising an uncomfortable question: if the foundation ignores half of human experience, how scientific are we really? In this episode, Dr Eeks talks with physician‑author Dr Robert Smith about why his new book Has Medicine Lost Its Mind? argues it is time to reunite what never should have been divided. 

What We Cover

• The Great Split: A medieval Church decree let scientists dissect bodies but barred them from the head, setting up the mental‑vs‑physical divide that still guides clinical practice.
• Primary‑Care Patchwork: Family doctors now manage roughly 75 percent of U.S. mental‑health care despite minimal formal training in mental health.
• Medicalizing Real‑Life Messes: Trauma, chronic stress, and tough social conditions often get reframed as diseases because the system lacks better options.
• The “Complex” Patient Label: How “complex” often translates to “we’re overwhelmed and don’t know what’s really wrong.”
• Culture on Autopilot: Rituals, hierarchy, and resistance to change can block genuine healing even when evidence points elsewhere.
• A Way Forward: The biopsychosocial model that addresses lab values and life stories—and what it would take for mainstream medicine to embrace it.

If you have ever felt that your doctor’s office visit left half of you outside the exam room, press play and join the conversation about what real, whole‑person healthcare could look like.

 Dr. Robert C. Smith is a nationally acclaimed authority on evidence‑based mental health care and doctor–patient communication. A University Distinguished Professor of Medicine and Psychiatry at Michigan State University, he pioneered the first patient‑centered training approach that teaches clinicians how to forge strong, collaborative relationships with their patients. His contributions have earned him numerous honors, including Master status from the American College of Physicians and the prestigious George Engel Award for Outstanding Research. Dr. Smith has authored more than 150 peer‑reviewed articles and continues to garner hundreds of academic citations each year. His expertise has been featured in outlets such as The New York Times, The Wall Street Journal, and The Today Show, and he writes regularly for Psychology Today. 

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In this episode of Causes or Cures, Dr. Eeks chats with immunology expert Dr. Maziar “Maz” Divangahi about how a fiber found in mushrooms may help us beat the flu, and he introduces us to the concept of disease tolerance. 

What We’ll Cover

1. Beta-Glucan 101
   • What it is: a natural fiber in the outer wall of fungi (think mushrooms).
   • Why it matters: mounting evidence says it can help you fight off the flu by improving something called disease tolerance. 
2. Two Immune Playbooks
   • Host Resistance: the classic “seek and destroy” tactic.
   • Disease Tolerance: a quieter, damage-control strategy our bodies use to stay functional even when a pathogen sticks around.
   • Dr. Maz will unpack how beta-glucan may tilt the balance toward disease tolerance.
3. From TB Labs to Flu Research
   • Insights from Dr. Maz’s tuberculosis studies that set the stage for his beta-glucan–flu work.
   • Early data on how this fungal fiber might boost flu-specific disease tolerance.
4. Should We Eat More Mushrooms or Supplement?
   • Practical tips and caveats on dietary vs. supplemental beta-glucan.
   • What the current evidence actually supports.
5. Beyond Infections: Beta-Glucan in Cancer Trials
   • Snapshot of ongoing studies in breast and bladder cancer.
   • Why disease tolerance is a hot oncology frontier.
6. Future Directions & Take-Home Points
   • Where Dr. Maz’s research is headed next.
   • Simple, science-backed actions listeners can try today.

Listen If You’ve Ever Wondered…

• Why some people sail through the flu while others end up in the ER.
• Whether “disease tolerance” might rewrite how we tackle pandemics.
• If tossing extra shiitakes into your stir-fry can really make a difference.

Dr. Maziar (Maz) Divangahi is a Professor of Medicine at McGill University. He is the Associate Director of the Meakins-Christie Laboratories and the Associate Director of the McGill Interna onal TB Centre. He is an internationally recognized pulmonary immunologist and the overarching focus of his research program is to inves gate the regulatory mechanisms involved in host resistance and disease tolerance against major pulmonary bacterial (Mycobacterium tuberculosis) and viral (influenza virus and SARS-CoV2) pathogens. He is currently inves ga ng how to harness the power of innate memory response (Trained Immunity) in vaccine development. Throughout his career, he has been a prolifera ve inves gator publishing in outstanding journals and received numerous awards, including a CIHR New Inves gator Award, FRQS Award, and the CIHR Founda on grant. His scholarly work has been recognized by elec on to the Royal Society of Canada. He is currently holding the Strauss Chair in Respiratory Diseases. 

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In this episode, Dr. Eeks sits down with world-renowned cardiologist and nutrition dynamo Dr. Kim Williams to pull the lid off “healthy” plant-based restaurant meals, and a whole lot more.

What’s on the menu:

• First-of-its-kind restaurant study – How Dr. Williams scored plant-based dishes for heart health, what shocked him, and the sneaky “health halo” traps you’ll now spot a mile away.
• Plant-based vs. junk-based – Could plant-based be sliding toward the same fate as the Western diet? He breaks down where things are headed and how to dodge the pitfalls.
• Cardio-nutrition deep dive – The eating plan Dr. Williams follows himself, plus straight talk on saturated fat, carbs, sugar, cholesterol, animal welfare, and factory farming.
• Big-picture fixes – Population-level policies he believes could actually move the needle on improving nutrition at the public health level.

If you eat out, care about your heart, or just want the unvarnished science behind plant-powered plates, this episode is packed with gems you won’t want to miss.

Dr. Kim Allan Williams, MD, MACC, FAHA, MASNC, FESC is Chair of Medicine at the University of Louisville and a triple-threat in general, preventive, and cardiovascular-imaging cardiology. He’s a former President of both the American College of Cardiology and the American Society of Nuclear Cardiology, and he previously led the Association of Black Cardiologists as Board Chair. At Wayne State he launched the Urban Cardiology Initiative, and later created Rush University’s H.E.A.R.T. Program (Helping Everyone Assess Risk Today)—community screenings that pair education, nutrition, and lifestyle coaching. A lifelong advocate for nutrition literacy, health-equity, and system-wide reform, Dr. Williams has advised the FDA, CMS, and served more than 25 years as an AMA delegate. Most recently, he sat on the 2022 task force that briefed the White House Conference on Nutrition, Health, and Hunger.

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In this episode of Causes or Cures, Dr. Eeks chats with Erin Williamson, a national expert on child trafficking and a leader at Love146, an organization dedicated to ending child trafficking and caring for its survivors.

We dive deep into what child trafficking really is—both labor and sex trafficking—and explore its prevalence, evolving risk factors, and the role social media plays in recruitment. Erin breaks down how traffickers often target children, sometimes people they know, and how some do it through the internet. She shares eye-opening examples and challenges some of the most persistent myths we’ve seen in media, pop culture, and even online activism.

We also explore:

• What makes a child more vulnerable to trafficking?
• Is child trafficking really increasing?
• Are "rescue missions" always the best path to freedom, or can they sometimes do harm?
• Why the idea that traffickers lurk in white vans is outdated and unhelpful.
• And why it’s not just girls who are trafficked for sex.

Erin also explains what Love146 actually does—why the name “Love146” matters—and offers practical, evidence-based tips for parents who want to protect their kids in a digital world. Finally, we talk public health and policy: What needs to change at the systems level to better prevent trafficking in the first place?

Erin is the Chief Programs & Strategy Officer at Love146, where she leads efforts to prevent child trafficking and exploitation. With over 20 years of experience in social services and child protection, Erin has developed trauma-informed programs that have reached thousands of vulnerable youth across the U.S. She is also a parent, advocate, and expert in human trafficking prevention and survivor care.

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Could gene drive mosquitoes be the key to ending deadly diseases like malaria and dengue or do the risks outweigh the benefits? 

In this episode of Causes or Cures, Dr. Eeks talks with Dr. Michael Santos about the controversial yet potentially groundbreaking technology known as gene drive. Unlike traditional genetically modified organisms, gene drive mosquitoes are engineered to pass on specific traits to nearly all of their offspring, drastically altering or suppressing mosquito populations that spread disease. With real-world field trials set to begin very soon, we dive into how this technology works, how it differs from standard genetic modification, what diseases it targets, and what could go wrong. We also explore how the trials will be conducted, regulated, and monitored to ensure safety and transparency. Is this the dawn of a public health breakthrough or are we opening a Pandora’s box we can’t close? 

Dr. Michael Santos is the Senior Vice President of Science Partnerships and Chief Population Health Science Officer at the Foundation for the NIH. He leads global programs focused on biomedical innovation and health equity, and directs the GeneConvene Global Collaboration, which supports informed decision-making around genetic biocontrol technologies like gene drive. Prior to this, he held leadership roles at the Bill & Melinda Gates Foundation and was a Principal at Boston Consulting Group, working across global health strategy. Dr. Santos began his career in astronomy and holds a Ph.D. from Caltech. 

To learn more about GeneConvene, Gene Drive Mosquitoes (and gain access to the infographic discussed in the episode) please click here. 

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In this episode of Causes or Cures, Dr. Eeks chats with Professor Maureen Cropper, Chair of the Economics Department at the University of Maryland and a leading environmental economist, about her recent research on the health and economic impacts of toxic chemicals in plastics.

We explore how an economist came to study chemical exposures and what her research reveals about the true cost of common compounds found in everyday plastic products. The conversation focuses on three major groups of toxic chemicals (BPA, DEHP, and PBDEs) and the serious health risks linked to them. Professor Cropper explains where these chemicals are commonly found, who is most at risk, and how she estimated both the public health burden and the economic costs tied to ongoing exposure.

You’ll also hear about what she believes needs to change: the policy actions, regulatory strategies, and paradigm shifts necessary to move toward safer, healthier materials. 

If you're concerned about chemicals in consumer products, interested in environmental health policy, or curious how economists quantify health risks, this episode is a great listen! 

Professor Maureen Cropper is a Distinguished University Professor of Economics at the University of Maryland and Chair of the Economics Department. She is also a Senior Fellow at Resources for the Future and a former Lead Economist at the World Bank. Dr. Cropper is a member of the National Academy of Sciences and a Research Associate at the National Bureau of Economic Research. Her research focuses on valuing environmental amenities, estimating consumer preferences for health and longevity improvements, and analyzing the trade-offs inherent in environmental regulations. Her recent work examines the public health and economic impacts of toxic chemicals found in plastics. 

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In this episode of Causes or Cures, we explore insights into brain health and longevity with NYT bestselling author and neurologist Dr. Dale Bredesen.

Dr. Bredesen explains why he believes cognitive decline is not an inevitable part of aging and outlines six biological processes he identifies as impacting brain aging. He also shares practical tools he recommends for assessing how well your mind is functioning. 

We discuss the alarming rise in early-onset dementia among people in their 30s and 40s and the potential causes behind this increase. Dr. Bredesen also talks about the links between COVID, sugar intake, and dementia risk. He offers science-based advice on diet, sleep, and lifestyle strategies that support an ageless brain.

Additionally, Dr. Bredesen addresses how the for-profit healthcare system can hinder Alzheimer’s management and shares his comprehensive ReCODE Protocol™, which he presents as a promising approach to preventing and potentially reversing cognitive decline, though it has sparked passionate discussions and differing opinions in the Alzheimer's and broader medical communities.

About Dr. Dale Bredesen
Dr. Bredesen is an internationally recognized expert in neurodegenerative diseases and the author of The Ageless Brain and The End of Alzheimer's Disease. He earned his M.D. from Duke University Medical Center, completed his neurology residency at UCSF, and was an NIH Postdoctoral Fellow in Nobel laureate Stanley Prusiner’s laboratory. He has held faculty positions at UCSF, UCLA, and UC San Diego, and was founding President and CEO of the Buck Institute for Research on Aging. Dr. Bredesen’s pioneering research has led to innovative treatments and the development of the ReCODE Protocol™, offering new hope in the fight against Alzheimer’s disease.

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In this episode of Causes or Cures, Dr. Eeks sits down with Dr. Jasmin Mujkanovic, a cardiologist and researcher from Copenhagen University Hospital, to explore a critical question: Could certain antidepressants be linked to sudden cardiac death?

Dr. Mujkanovic breaks down the findings from his recent study, which was presented at the 2025 European Heart Rhythm Association (EHRA) Conference. He begins by explaining what sudden cardiac death actually is, and why it drew his scientific curiosity. From there, he walks us through how the study was conducted, the types of antidepressants examined, and what the data revealed. He unpacks possible biological mechanisms behind the observed link, key takeaways for both patients and clinicians, and the broader implications for mental health and heart health.

Whether you're a healthcare professional, someone taking antidepressants, or simply curious about the intersection of mental and heart health, this is a conversation you don’t want to miss.

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In this episode of Causes or Cures, Dr. Eeks chats with aging and longevity expert Dr. Heike Bischoff-Ferrari about whether simple lifestyle interventions, like supplementation and exercise, can actually make us biologically younger.

Dr. Bischoff-Ferrari breaks down:
 • What DNA methylation clocks are and how they’re used to measure biological age

•   The design and findings of the DO-HEALTH Bio-Age Trial
•   Whether vitamin D, algae-based omega-3s, and exercise can turn back your biological clock
•   The science behind how these interventions may work
•   Practical takeaways for longevity and healthy aging
•   What’s next in this fast-moving field

Dr. Bischoff-Ferrari is a physician and researcher with board certifications in geriatrics, internal medicine, and rehab. She’s a professor at the University of Zurich where she chairs the Department of Geriatrics and Aging Research, and the principal investigator of DO-HEALTH, Europe’s largest study ever on healthy longevity. With a doctorate from Harvard and a long-standing commitment to aging research, she’s at the forefront of understanding how to extend not just lifespan, but healthspan. You can learn more about her here. 

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Listen to the very short satire wellness audio book Yours in Wellness! 

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