How could a single psychedelic treatment cause lasting change? Joshua Siegel, MD, PhD, is on a mission to find out. A leading expert on neuroimaging and neuropsychopharmacology at NYU Langone’s Center for Psychedelic Medicine, Dr. Siegel unpacks how psilocybin may spark neuroplasticity and reshape the depressed brain. He also gives us an inside look at the race to develop non-hallucinogenic psychedelic analogs. 

Dr. Siegel is an assistant professor at NYU Grossman School of Medicine.

🔍 Topics Covered:

00:00 Introduction
00:15 Dr. Siegel's Current Work
01:01 Past Research and Human Psilocybin Imaging Study
02:39 Understanding Brain Changes and Biomarkers
06:13 Mechanisms of Action and Plasticity
12:51 Surprising Findings and Context Dependence
16:34 Challenges and Future Directions in Psychedelic Research
20:46 Advanced Imaging and Personalized Treatment Plans
24:15 Setbacks and Lessons in Psychedelic Medicine
28:40 Emerging Areas in Neuropsychopharmacology
31:46 Conclusion

📚 Related Resources:

Joshua Siegel, MD, PhD 
NYU Langone Health’s Center for Psychedelic Medicine
The Multidisciplinary Association for Psychedelic Studies (MAPS)
“Psychedelic and Dissociative Drugs as Medicines” (NIH) 

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This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

Senior Producer: Jon Earle