What if mental health care worked more like cancer treatment—tailored to the individual, informed by biology, and driven by data? Charles Marmar, MD, Chair of Psychiatry at NYU Grossman School of Medicine, takes us through the latest advances in precision psychiatry. From brain imaging to digital phenotyping, Dr. Marmar outlines the tools shaping a future where treatment is fully customized. He also shares stories from the front lines: a patient whose depression was treated with the help of a brain biopsy, why PTSD and depression aren’t one-size-fits-all, and how quantum computing could radically accelerate psychiatric research.

🔍 Topics Covered

00:00 Introduction
02:24 Personalized Treatment Approaches
05:13 Challenges in Precision Psychiatry
11:12 The Role of Genomics and Brain Imaging
23:35 Digital Psychiatry and AI
25:57 Quantum Computing in Psychiatry
33:04 Future of Precision Psychiatry
37:22 Conclusion

📚 Related Resources

Charles Marmar, MD – NYU Faculty Profile
NYU Langone Psychiatry
Adriana Heguy, PhD – NYU Faculty Profile
Javad Shabani, PhD – NYU Faculty Profile

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Executive Producer: Jon Earle

There’s a care model for schizophrenia that actually works—why isn’t it everywhere? On this episode, W. Gordon Frankle, MD, MBA, Vice Chair of Psychiatry at NYU Langone Health, shares how his team in Brooklyn is building a new model for treating serious mental illness—one rooted in long-term, relationship-driven, team-based care. From wraparound services to precision psychiatry, this conversation explores what happens when you bring humanity, structure, and innovation to a population too often left behind.

Also discussed:

• The first novel schizophrenia drug in over 50 years (Cobenfy)
• Why clozapine is underused—and how that may finally change
• The potential of brain imaging and biomarkers in psychiatric treatment
• What a real community mental health system looks like
• Why trust, not just treatment, is essential for recovery

🔍 Topics Covered

00:00 Introduction
00:30 Dr. Frankle's Current Work
01:08 Advancements in Schizophrenia Research
02:29 Challenges and New Treatments in Schizophrenia
05:02 Precision Medicine in Psychiatry
05:59 PET Scans and Brain Energetics
09:46 Barriers to Effective Treatment
11:51 Clozapine and Treatment Access
13:38 Wraparound Services and Community Care
14:46 Early Screening and Public Health Interventions
18:32 Mandated Treatment and Patient Engagement
30:08 Homelessness and Mental Health
34:54 Future Directions in Schizophrenia Treatment
38:09 Conclusion

📚 Related Resources

W. Gordon Frankle, MD, MBA
Schizophrenia care at NYU Langone
NYU Langone Hospital—Brooklyn
3 Things to Know About Cobenfy (Yale Medicine)

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Executive Producer: Jon Earle

How could a single psychedelic treatment cause lasting change? Joshua Siegel, MD, PhD, is on a mission to find out. A leading expert on neuroimaging and neuropsychopharmacology at NYU Langone’s Center for Psychedelic Medicine, Dr. Siegel unpacks how psilocybin may spark neuroplasticity and reshape the depressed brain. He also gives us an inside look at the race to develop non-hallucinogenic psychedelic analogs. 

Dr. Siegel is an assistant professor at NYU Grossman School of Medicine.

🔍 Topics Covered:

00:00 Introduction
00:15 Dr. Siegel's Current Work
01:01 Past Research and Human Psilocybin Imaging Study
02:39 Understanding Brain Changes and Biomarkers
06:13 Mechanisms of Action and Plasticity
12:51 Surprising Findings and Context Dependence
16:34 Challenges and Future Directions in Psychedelic Research
20:46 Advanced Imaging and Personalized Treatment Plans
24:15 Setbacks and Lessons in Psychedelic Medicine
28:40 Emerging Areas in Neuropsychopharmacology
31:46 Conclusion

📚 Related Resources:

Joshua Siegel, MD, PhD 
NYU Langone Health’s Center for Psychedelic Medicine
The Multidisciplinary Association for Psychedelic Studies (MAPS)
“Psychedelic and Dissociative Drugs as Medicines” (NIH) 

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Executive Producer: Jon Earle

What if a simple conversation in the emergency room could reveal who’s most at risk for PTSD before symptoms even begin? Katharina Schultebraucks, PhD, shares her innovative work on using machine learning to forecast mental health outcomes and explains how AI could revolutionize how we detect, prevent, and treat psychiatric disorders. Dr. Schultebraucks is Co-Director of the Computational Psychiatry Program and Associate Professor in the Department of Psychiatry and Population Health at NYU Grossman School of Medicine.

🔍 Topics Covered
00:00 Introduction
00:23 Current Work and Research Focus
01:29 Objective Measures in Psychiatry
02:50 Predicting PTSD Risk
04:28 Early Preventive Interventions
05:47 Machine Learning in Mental Health
09:49 Challenges and Surprises in Research
22:46 Burnout in Emergency Department Providers
27:17 Precision Psychiatry and Future Directions
29:35 Conclusion

📚 Related Resources
-Katharina Schultebraucks, PhD
-Computational Psychiatry Program in NYU Langone’s Department of Psychiatry
-“Dissecting racial bias in an algorithm used to manage the health of populations” by Ziad Obermeyer, et al
-PTSD Treatment at NYU Langone Health 

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Executive Producer: Jon Earle

How do you help a child with ADHD stay organized, on task, and confident in school? Richard Gallagher, PhD, a child and adolescent psychologist at NYU Langone Health, shares groundbreaking research on organizational skills training for children with ADHD—a behavioral treatment that’s changing lives and improving classroom performance. This episode dives into how executive functioning challenges manifest in real life, the strengths (and limits) of technology, and the power of parent training and therapeutic coaching to help children thrive.

Dr. Richard Gallagher is Associate Professor in the Department of Child and Adolescent Psychiatry at NYU Grossman School of Medicine, and Director of the Organization Skills Program.

🔍 Topics Covered

00:00 Introduction
00:19 Current Research on Organizational Skills
01:06 Executive Functioning and Practical Interventions
02:37 Impact of Interventions on ADHD
04:41 Expanding Research and Brain Connectivity
05:08 Medication and Organizational Skills
08:11 Technology in ADHD Assessment
15:39 Effective Parenting Styles for ADHD
23:10 Non-Pharmacological Treatments and Future Research
25:58 Conclusion and Final Thoughts

📚 Related Resources

👨‍⚕️More about Dr. Richard Gallagher
🔬 NYU Child Study Center
📘 “Organizational Skills Training for Children with ADHD” by Richard Gallagher, Howard B. Abikoff, and Elana G. Spira 
📝 CHADD Parent Training Resources
📈 CDC ADHD Parent Guide

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Executive Producer: Jon Earle

ADHD isn’t just a childhood condition—many adults go undiagnosed for years. Lenard Adler, MD, Director of the Adult ADHD Program at NYU Langone Health, breaks down the nuances of ADHD in adults, the challenges of proper diagnosis, and the latest treatments available. Learn about his research, the screening tools his team has developed, and what’s on the horizon for adult ADHD care.

🔍 Topics Covered:

00:00 Introduction
00:44 Dr. Adler’s Current Research Focus
01:47 Importance of Proper Assessment
03:44 Challenges in Diagnosing Adult ADHD
06:15 Gender Differences in ADHD Diagnosis
07:51 Impact of ADHD on Lifespan
10:10 Comorbidities and Treatment Approaches
14:54 Medication and Treatment Strategies
21:15 Medication Shortages and Solutions
28:42 Recent Developments in ADHD Research
35:01 Screening and Diagnostic Tools
37:33 Conclusion

📚 Related Resources:

• Lenard A. Adler, MD (official bio)
• Adult ADHD Program at NYU Langone Health
• Adult Self-Report Scale (ASRS) Screener
• Life expectancy and years of life lost for adults with diagnosed ADHD in the UK: matched cohort study | The British Journal of Psychiatry
• American Professional Society of ADHD and Related Disorders (APSARD)
• CHADD: ADHD Resources and Support

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Executive Producer: Jon Earle

Despite affecting more Americans than diabetes, substance use is often left out of routine medical care. In this episode, NYU Langone Health’s Jennifer McNeely, MD—a clinician investigator, primary care and addiction medicine physician—explains why that must change. From the surprising history behind addiction’s exclusion from mainstream medicine to the innovative screening tools shaping the future of care, this conversation is a must-listen for anyone interested in addiction care and healthcare policy.

Jennifer McNeely, MD, is an Associate Professor of Medicine and Population Health at NYU Grossman School of Medicine and co-director of the Section on Tobacco, Alcohol, and Drug Use.

🔍 Topics Covered:

00:00 – Introduction
01:15 – Why addiction hasn’t been part of traditional medical care
05:00 – What medications can primary care providers actually prescribe?
07:00 – Why lifting legal barriers isn’t enough
08:00 – Making substance use screening part of routine care
11:50 – The power of self-report screening tools
13:30 – What primary care physicians can actually do after screening
16:10 – Real-world clinical impact of identifying substance use
18:00 – Overcoming stigma and “we don’t do that here” culture
22:17 – Can AI help with screening and care prioritization?

📚 Related Resources:

Jennifer McNeely, MD
Addiction Treatment at NYU Langone
NIDA’s Resources for Clinicians
Substance Use Screening Tools (NIDA)

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Executive Producer: Jon Earle

What makes addiction treatment truly effective? Behavioral scientist Charles Neighbors, MBA, PhD, shares groundbreaking research on the importance of therapeutic relationships, harm reduction, and human connection—love!—in treating substance use disorders. Dr. Neighbors is an Associate Professor in the Departments of Population Health, and Psychiatry at NYU Grossman School of Medicine.

💡 Topics Covered

00:00 Introduction to Dr. Charles Neighbors
01:37 The biggest challenges in addiction treatment
02:24 The Importance of Therapeutic Relationships
05:59 Defining “good treatment” and why love matters
08:05 The role of therapeutic alliance in patient outcomes
14:06 Barriers to change in addiction treatment systems (incl. stigma)
22:04 Harm reduction and safe injection sites: What does the science say?
30:36 Future directions in addiction policy and treatment

📚 Related Resources

• Charles J. Neighbors, MBA, PhD (official bio)
• Dr. Neighbors’ Lab - Health Evaluation & Analytics Lab (HEAL)
• Addiction Treatment at NYU Langone
• Understanding Harm Reduction: National Institute on Drug Abuse (NIDA)
• "Motivational Interviewing" by William R. Miller and Stephen Rollnick
• Community Reinforcement and Family Training (CRAFT)
• SAMHSA’s National Helpline for Mental Health, Drug, Alcohol Issues
• New York State Office of Addiction Services and Supports (OASAS)

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Executive Producer: Jon Earle

For the final episode of Season 2, we're joined by Dr. Samuele Cortese, Professor of Child and Adolescent Psychiatry at the University of Southampton (UK) and Adjunct Full Professor at NYU Langone. Together we explore the intersection of pediatric ADHD and precision psychiatry, including the disorder’s genetic underpinnings and evolving treatment options.

00:00 Introduction
00:54 Dr. Cortese's Research Journey
02:11 Global Perspectives and Challenges in ADHD Treatment
03:51 Advances in ADHD Diagnosis and Treatment
06:41 Role of Genetics in ADHD
09:33 Precision Treatment and Stratification
12:17 Treatment Adherence and Shared Decision-Making
23:55 Connection Between ADHD and Obesity
28:39 Non-Stimulant Alternatives and Future Directions in ADHD Treatment
32:16 Non-Pharmacological Treatments
37:28 Advice for Clinicians and Closing Thoughts

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Executive Producer: Jon Earle

Dr. Timothy Wilens is a Professor of Psychiatry at Harvard Medical School and Chief of the Division of Child and Adolescent Psychiatry at Massachusetts General Hospital. His research interest include the relationship between ADHD, bipolar disorder, and substance use disorders; ADHD pharmacotherapy; and stimulant medication misuse.

On this episode, Dr. Wilens discusses the importance of early diagnosis and intervention in ADHD, as well as its lifelong implications. He takes us through the evolution of ADHD treatment, from behavioral therapies to modern pharmacological interventions, including stimulant and non-stimulant medications, and the application of digital therapeutics. The conversation also touches on the stigma surrounding ADHD, the role of precision medicine, and the future of ADHD research.

00:00 Introduction
02:50 Evolution of ADHD Treatment
04:43 Stigma and Misconceptions
12:18 Importance of Early Intervention
15:02 ADHD Symptoms and Treatment Approaches
30:02 Addressing Concerns About Stimulant Medications
35:50 Navigating the Complexities of ADHD Medication
41:22 Future of ADHD Research and Treatment
43:20 Conclusion

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Executive Producer: Jon Earle